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Structure-Based Design of a Macrocyclic PROTAC
Andrea Testa
, Scott J. Hughes
, Xavier Lucas
,
Jane E. Wright
,
Alessio Ciulli
(Lead / Corresponding author)
Biological Chemistry and Drug Discovery
Research output
:
Contribution to journal
›
Article
›
peer-review
206
Citations (Scopus)
637
Downloads (Pure)
Overview
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Projects
(3)
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Dive into the research topics of 'Structure-Based Design of a Macrocyclic PROTAC'. Together they form a unique fingerprint.
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Keyphrases
Structure-based Design
100%
Proteolysis Targeting chimera (PROTAC)
100%
Bromodomain
66%
Bromodomain-containing Protein 4 (BRD4)
66%
Macrocyclization
66%
Cell Behavior
33%
Linker
33%
Rational Design
33%
Receptor Antagonist
33%
Binding Affinity
33%
Co-crystal Structure
33%
Ternary Complex
33%
Enzyme Inhibitors
33%
Chemical Probes
33%
Biophysical Studies
33%
Degrader
33%
Bifunctional Molecules
33%
BET Proteins
33%
PROTAC Degraders
33%
Homologous Target
33%
Bioactive Conformation
33%
Functional Chemicals
33%
Biochemistry, Genetics and Molecular Biology
Bromodomain
100%
Binding Affinity
50%
Crystal Structure
50%
Conformation
50%
Receptor Antagonist
50%
Ternary Complex
50%
Enzyme Inhibitor
50%
Chemistry
Proteolysis Targeting Chimera
100%
macrocyclization
50%
Crystal Structure
25%
Kd
25%
Enzyme Inhibitor
25%
Agent Interacting With Transmitter, Hormone or Drug Receptor
25%