Structure-based virtual screening for the identification of RNA-binding ligands

Peter Daldrop, Ruth Brenk

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    5 Citations (Scopus)


    Structure-based virtual screening exploits the 3D structure of the target as a template for the discovery of new ligands. It is a key method for hit discovery and was originally developed for protein targets. Recently, this method has also been applied to RNA targets. This chapter gives an overview of this method and its application in the context of ligand discovery for RNA. In addition, it describes in detail how to conduct virtual screening for RNA targets, making use of software that is free for noncommercial use. Some advice on how to avoid common pitfalls in virtual screening is also given.
    Original languageEnglish
    Title of host publicationTherapeutic applications of ribozymes and riboswitches
    Subtitle of host publicationmethods and protocols
    EditorsDaniel Lafontaine, Audrey Dubé
    PublisherHumana Press
    Number of pages13
    ISBN (Electronic)9781627037303
    ISBN (Print)9781627037297
    Publication statusPublished - 2014

    Publication series

    NameMethods in Molecular Biology
    PublisherHumana Press
    ISSN (Print)1064-3745


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