Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities

  • Carles Galdeano
  • , Morgan S. Gadd
  • , Pedro Soares
  • , Salvatore Scaffidi
  • , Inge Van Molle
  • , Ipek Birced
  • , Sarah Hewitt
  • , David M. Dias
  • , Alessio Ciulli (Lead / Corresponding author)

    Research output: Contribution to journal › Article › peer-review

    341 Citations (Scopus)
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    Keyphrases

    Biochemistry, Genetics and Molecular Biology

    Pharmacology, Toxicology and Pharmaceutical Science