Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii

A. Dawson, P. Trumper, G. Chrysostomou, W. N. Hunter

    Research output: Contribution to journalArticle

    Abstract

    The bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase (RibD) represents a potential antibacterial drug target. The structure of recombinant Acinetobacter baumannii RibD is reported in orthorhombic and tetragonal crystal forms at 2.2 and 2.0 Å resolution, respectively. Comparisons with orthologous structures in the Protein Data Bank indicated close similarities. The tetragonal crystal form was obtained in the presence of guanosine monophosphate, which surprisingly was observed to occupy the adenine-binding site of the reductase domain.
    Original languageEnglish
    Pages (from-to)611-617
    Number of pages7
    JournalActa Crystallographica F-Structural Biology and Crystallization Communications
    Volume69
    Issue number6
    DOIs
    Publication statusPublished - 2013

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