Structure of the mouse calpain small subunit gene

J. Simon C. Arthur, Peter A. Greer, John S. Elce

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    The calpains comprise a family of heterodimeric (80+28 kDa) Ca2+-dependent cysteine proteases, probably having roles in signal transduction and cytoskeletal remodelling. We describe cloning and sequencing of the 28 kDa calpain subunit cDNA from mouse (coding for 268 amino acids), and characterization of its gene. The gene spans 7 kb and contains 11 exons. The promoter region, like those of other calpain genes, lacks an obvious TATA box, but contains several Sp1 binding sites.

    Original languageEnglish
    Pages (from-to)247-252
    Number of pages6
    JournalBiochimica et Biophysica Acta. Protein Structure and Molecular Enzymology
    Volume1388
    Issue number1
    DOIs
    Publication statusPublished - 14 Oct 1998

    Keywords

    • Polymerase Chain Reaction
    • DNA, Complementary
    • Animals
    • Promoter Regions, Genetic
    • Base Sequence
    • Blotting, Southern
    • Molecular Sequence Data
    • Calpain
    • Mice
    • Amino Acid Sequence

    Fingerprint Dive into the research topics of 'Structure of the mouse calpain small subunit gene'. Together they form a unique fingerprint.

  • Cite this