Structure of the mouse calpain small subunit gene

J. Simon C. Arthur, Peter A. Greer, John S. Elce

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)


    The calpains comprise a family of heterodimeric (80+28 kDa) Ca2+-dependent cysteine proteases, probably having roles in signal transduction and cytoskeletal remodelling. We describe cloning and sequencing of the 28 kDa calpain subunit cDNA from mouse (coding for 268 amino acids), and characterization of its gene. The gene spans 7 kb and contains 11 exons. The promoter region, like those of other calpain genes, lacks an obvious TATA box, but contains several Sp1 binding sites.

    Original languageEnglish
    Pages (from-to)247-252
    Number of pages6
    JournalBiochimica et Biophysica Acta. Protein Structure and Molecular Enzymology
    Issue number1
    Publication statusPublished - 14 Oct 1998


    • Polymerase Chain Reaction
    • DNA, Complementary
    • Animals
    • Promoter Regions, Genetic
    • Base Sequence
    • Blotting, Southern
    • Molecular Sequence Data
    • Calpain
    • Mice
    • Amino Acid Sequence


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