Abstract
Isoprenoid precursor synthesis via the mevalonate route in humans and pathogenic trypanosomatids is an important metabolic pathway. There is however, only limited information available on the structure and reactivity of the component enzymes in trypanosomatids. Since isoprenoid biosynthesis is essential for trypanosomatid viability and may provide new targets for therapeutic intervention it is important to characterize the pathway components.
Original language | English |
---|---|
Pages (from-to) | 20-35 |
Number of pages | 16 |
Journal | BMC Structural Biology |
Volume | 7 |
DOIs | |
Publication status | Published - 2007 |
Keywords
- Animals
- Crystallography, X-Ray
- Leishmania major
- Models, Molecular
- Phosphotransferases (Alcohol Group Acceptor)
- Protein Conformation
- Substrate Specificity