Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase

Tanja Sgraja, Terry K Smith, William N Hunter

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)

    Abstract

    Isoprenoid precursor synthesis via the mevalonate route in humans and pathogenic trypanosomatids is an important metabolic pathway. There is however, only limited information available on the structure and reactivity of the component enzymes in trypanosomatids. Since isoprenoid biosynthesis is essential for trypanosomatid viability and may provide new targets for therapeutic intervention it is important to characterize the pathway components.
    Original languageEnglish
    Pages (from-to)20-35
    Number of pages16
    JournalBMC Structural Biology
    Volume7
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Animals
    • Crystallography, X-Ray
    • Leishmania major
    • Models, Molecular
    • Phosphotransferases (Alcohol Group Acceptor)
    • Protein Conformation
    • Substrate Specificity

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