Abstract
The dynamic interplay between collective cell movement and the various molecules
involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes enables a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this work we establish a general spatio-temporal-structural framework that enables the description of surface- bound reaction processes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with two concrete examples arising from cancer invasion.
involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes enables a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this work we establish a general spatio-temporal-structural framework that enables the description of surface- bound reaction processes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with two concrete examples arising from cancer invasion.
| Original language | English |
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| Publication status | Published - 2015 |
| Event | New Mathematical and Computational Problems involved in Cell Motility, Morphogenesis and Pattern Formation: International Conference Part of the Six-Months Thematic Programme “Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation” 13 June-18 December 2015, Isaac Newton Institute, Cambridge, UK - Isaac Newton Institute, Cambridge, United Kingdom Duration: 7 Dec 2015 → 11 Dec 2015 |
Conference
| Conference | New Mathematical and Computational Problems involved in Cell Motility, Morphogenesis and Pattern Formation |
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| Country/Territory | United Kingdom |
| City | Cambridge |
| Period | 7/12/15 → 11/12/15 |
