Structured Models of Cell Migration Incorporating Membrane Reactions (Keynote Speaker Talk)

Dumitru Trucu

Structured Models of Cell Migration Incorporating Membrane Reactions (Keynote Speaker Talk)

Dumitru Trucu

Mathematics

Research output: Contribution to conference › Paper

Abstract

The dynamic interplay between collective cell movement and the various molecules
involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes enables a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this work we establish a general spatio-temporal-structural framework that enables the description of surface- bound reaction processes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with two concrete examples arising from cancer invasion.

Original language	English
Publication status	Published - 2015
Event	New Mathematical and Computational Problems involved in Cell Motility, Morphogenesis and Pattern Formation: International Conference Part of the Six-Months Thematic Programme “Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation” 13 June-18 December 2015, Isaac Newton Institute, Cambridge, UK - Isaac Newton Institute, Cambridge, United Kingdom Duration: 7 Dec 2015 → 11 Dec 2015

Conference

Conference	New Mathematical and Computational Problems involved in Cell Motility, Morphogenesis and Pattern Formation
Country/Territory	United Kingdom
City	Cambridge
Period	7/12/15 → 11/12/15

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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title = "Structured Models of Cell Migration Incorporating Membrane Reactions (Keynote Speaker Talk)",

abstract = "The dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes enables a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this work we establish a general spatio-temporal-structural framework that enables the description of surface- bound reaction processes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with two concrete examples arising from cancer invasion.",

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note = "New Mathematical and Computational Problems involved in Cell Motility, Morphogenesis and Pattern Formation : International Conference Part of the Six-Months Thematic Programme “Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation” 13 June-18 December 2015, Isaac Newton Institute, Cambridge, UK ; Conference date: 07-12-2015 Through 11-12-2015",

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T1 - Structured Models of Cell Migration Incorporating Membrane Reactions (Keynote Speaker Talk)

AU - Trucu, Dumitru

PY - 2015

Y1 - 2015

N2 - The dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes enables a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this work we establish a general spatio-temporal-structural framework that enables the description of surface- bound reaction processes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with two concrete examples arising from cancer invasion.

AB - The dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes enables a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this work we establish a general spatio-temporal-structural framework that enables the description of surface- bound reaction processes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with two concrete examples arising from cancer invasion.

UR - https://www.newton.ac.uk/seminar/20151207153016151

M3 - Paper

T2 - New Mathematical and Computational Problems involved in Cell Motility, Morphogenesis and Pattern Formation

Y2 - 7 December 2015 through 11 December 2015

ER -

Structured Models of Cell Migration Incorporating Membrane Reactions (Keynote Speaker Talk)

Abstract

Conference

UN SDGs

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