Structured models of cell migration incorporating molecular binding processes

Pia Domschke (Lead / Corresponding author), Dumitru Trucu, Alf Gerisch, Mark A. J. Chaplain

Research output: Contribution to journalArticle

10 Citations (Scopus)
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Abstract

The dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes allows a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this paper we establish a general spatio-temporal-structural framework that enables the description of molecular binding to cell membranes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with two examples arising from cancer invasion.
Original languageEnglish
Pages (from-to)1517-1561
Number of pages45
JournalJournal of Mathematical Biology
Volume75
Issue number6-7
Early online date12 Apr 2017
DOIs
Publication statusPublished - Dec 2017

Keywords

  • Strucutred population model
  • Spatio-temporal model
  • Cell-surface receptors
  • Cancer invasion

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