Studying kinetochore kinases

Adrian T. Saurin (Lead / Corresponding author), Geert J. P. L. Kops

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    3 Citations (Scopus)
    202 Downloads (Pure)

    Abstract

    Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions. Describing the mechanisms and dynamics of their localized activation and deactivation is therefore instrumental for understanding the spatiotemporal control of chromosome segregation.

    Original languageEnglish
    Title of host publicationThe mitotic spindle
    Subtitle of host publicationmethods and protocols
    EditorsPaul Chang , Ryoma Ohi
    Place of PublicationNew York
    PublisherSpringer
    Pages333-347
    Number of pages15
    ISBN (Electronic)9781493935420
    ISBN (Print)9781493935406
    DOIs
    Publication statusPublished - 2016

    Publication series

    NameMethods in Molecular Biology
    PublisherSpringer
    Volume1413
    ISSN (Print)1064-3745
    ISSN (Electronic)1940-6029

    Keywords

    • Kinetochore
    • Kinase
    • Small molecule inhibitor
    • Anitbody
    • Signaling
    • Phosphorylation
    • Spindle checkpoint

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  • Cite this

    Saurin, A. T., & Kops, G. J. P. L. (2016). Studying kinetochore kinases. In P. Chang , & R. Ohi (Eds.), The mitotic spindle: methods and protocols (pp. 333-347). (Methods in Molecular Biology; Vol. 1413). Springer . https://doi.org/10.1007/978-1-4939-3542-0_21