Studying kinetochore kinases

Adrian T. Saurin; Geert J. P. L. Kops

doi:10.1007/978-1-4939-3542-0_21

Studying kinetochore kinases

Adrian T. Saurin (Lead / Corresponding author), Geert J. P. L. Kops

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

5 Citations (Scopus)

387 Downloads (Pure)

Abstract

Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions. Describing the mechanisms and dynamics of their localized activation and deactivation is therefore instrumental for understanding the spatiotemporal control of chromosome segregation.

Original language	English
Title of host publication	The mitotic spindle
Subtitle of host publication	methods and protocols
Editors	Paul Chang , Ryoma Ohi
Place of Publication	New York
Publisher	Springer
Pages	333-347
Number of pages	15
ISBN (Electronic)	9781493935420
ISBN (Print)	9781493935406
DOIs	https://doi.org/10.1007/978-1-4939-3542-0_21
Publication status	Published - 2016

Publication series

Name	Methods in Molecular Biology
Publisher	Springer
Volume	1413
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

Keywords

Kinetochore
Kinase
Small molecule inhibitor
Anitbody
Signaling
Phosphorylation
Spindle checkpoint

Access to Document

10.1007/978-1-4939-3542-0_21

Author Accepted Manuscript
The final publication is available at Springer via http://dx.doi.org/10.1007/978-1-4939-3542-0_21.
Accepted author manuscript, 1.63 MB

Kinase-Phosphatase Coupling at the Kinetochore and the Maintenance of Chromosomal Stability (joint with University of Edinburgh)
Saurin, A. (Investigator)
1/06/16 → 30/11/24
Project: Research

Cite this

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title = "Studying kinetochore kinases",

abstract = "Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions. Describing the mechanisms and dynamics of their localized activation and deactivation is therefore instrumental for understanding the spatiotemporal control of chromosome segregation.",

keywords = "Kinetochore, Kinase, Small molecule inhibitor, Anitbody, Signaling, Phosphorylation, Spindle checkpoint",

author = "Saurin, {Adrian T.} and Kops, {Geert J. P. L.}",

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T1 - Studying kinetochore kinases

AU - Saurin, Adrian T.

AU - Kops, Geert J. P. L.

N1 - © Springer Science+Business Media New York 2016.

PY - 2016

Y1 - 2016

N2 - Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions. Describing the mechanisms and dynamics of their localized activation and deactivation is therefore instrumental for understanding the spatiotemporal control of chromosome segregation.

AB - Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions. Describing the mechanisms and dynamics of their localized activation and deactivation is therefore instrumental for understanding the spatiotemporal control of chromosome segregation.

KW - Kinetochore

KW - Kinase

KW - Small molecule inhibitor

KW - Anitbody

KW - Signaling

KW - Phosphorylation

KW - Spindle checkpoint

U2 - 10.1007/978-1-4939-3542-0_21

DO - 10.1007/978-1-4939-3542-0_21

M3 - Chapter (peer-reviewed)

C2 - 27193859

SN - 9781493935406

T3 - Methods in Molecular Biology

SP - 333

EP - 347

BT - The mitotic spindle

A2 - Chang , Paul

A2 - Ohi , Ryoma

PB - Springer

CY - New York

ER -

Studying kinetochore kinases

Abstract

Publication series

Keywords

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Projects

Kinase-Phosphatase Coupling at the Kinetochore and the Maintenance of Chromosomal Stability (joint with University of Edinburgh)

Cite this