Studying kinetochore kinases

Adrian T. Saurin (Lead / Corresponding author), Geert J. P. L. Kops

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    2 Citations (Scopus)
    120 Downloads (Pure)

    Abstract

    Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions. Describing the mechanisms and dynamics of their localized activation and deactivation is therefore instrumental for understanding the spatiotemporal control of chromosome segregation.

    Original languageEnglish
    Title of host publicationThe mitotic spindle
    Subtitle of host publicationmethods and protocols
    EditorsPaul Chang , Ryoma Ohi
    Place of PublicationNew York
    PublisherSpringer
    Pages333-347
    Number of pages15
    ISBN (Electronic)9781493935420
    ISBN (Print)9781493935406
    DOIs
    Publication statusPublished - 2016

    Publication series

    NameMethods in Molecular Biology
    PublisherSpringer
    Volume1413
    ISSN (Print)1064-3745
    ISSN (Electronic)1940-6029

    Fingerprint

    M Phase Cell Cycle Checkpoints
    Kinetochores
    Chromosome Segregation
    Phosphoric Monoester Hydrolases
    Phosphotransferases
    Chromosomes

    Keywords

    • Kinetochore
    • Kinase
    • Small molecule inhibitor
    • Anitbody
    • Signaling
    • Phosphorylation
    • Spindle checkpoint

    Cite this

    Saurin, A. T., & Kops, G. J. P. L. (2016). Studying kinetochore kinases. In P. Chang , & R. Ohi (Eds.), The mitotic spindle: methods and protocols (pp. 333-347). (Methods in Molecular Biology; Vol. 1413). New York: Springer . https://doi.org/10.1007/978-1-4939-3542-0_21
    Saurin, Adrian T. ; Kops, Geert J. P. L. / Studying kinetochore kinases. The mitotic spindle: methods and protocols. editor / Paul Chang ; Ryoma Ohi . New York : Springer , 2016. pp. 333-347 (Methods in Molecular Biology).
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    keywords = "Kinetochore, Kinase, Small molecule inhibitor, Anitbody, Signaling, Phosphorylation, Spindle checkpoint",
    author = "Saurin, {Adrian T.} and Kops, {Geert J. P. L.}",
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    Saurin, AT & Kops, GJPL 2016, Studying kinetochore kinases. in P Chang & R Ohi (eds), The mitotic spindle: methods and protocols. Methods in Molecular Biology, vol. 1413, Springer , New York, pp. 333-347. https://doi.org/10.1007/978-1-4939-3542-0_21

    Studying kinetochore kinases. / Saurin, Adrian T. (Lead / Corresponding author); Kops, Geert J. P. L.

    The mitotic spindle: methods and protocols. ed. / Paul Chang ; Ryoma Ohi . New York : Springer , 2016. p. 333-347 (Methods in Molecular Biology; Vol. 1413).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    TY - CHAP

    T1 - Studying kinetochore kinases

    AU - Saurin, Adrian T.

    AU - Kops, Geert J. P. L.

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    N2 - Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions. Describing the mechanisms and dynamics of their localized activation and deactivation is therefore instrumental for understanding the spatiotemporal control of chromosome segregation.

    AB - Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions. Describing the mechanisms and dynamics of their localized activation and deactivation is therefore instrumental for understanding the spatiotemporal control of chromosome segregation.

    KW - Kinetochore

    KW - Kinase

    KW - Small molecule inhibitor

    KW - Anitbody

    KW - Signaling

    KW - Phosphorylation

    KW - Spindle checkpoint

    U2 - 10.1007/978-1-4939-3542-0_21

    DO - 10.1007/978-1-4939-3542-0_21

    M3 - Chapter (peer-reviewed)

    SN - 9781493935406

    T3 - Methods in Molecular Biology

    SP - 333

    EP - 347

    BT - The mitotic spindle

    A2 - Chang , Paul

    A2 - Ohi , Ryoma

    PB - Springer

    CY - New York

    ER -

    Saurin AT, Kops GJPL. Studying kinetochore kinases. In Chang P, Ohi R, editors, The mitotic spindle: methods and protocols. New York: Springer . 2016. p. 333-347. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-3542-0_21