Subcortical evoked activity and motor enhancement in Parkinson's disease.

Anam Anzak; Huiling Tan; Alek Pogosyan; Sadaquate Khan; Shazia Javed; Steven S. Gill; Ashkan Keyoumars; Harith Akram; Thomas Foltynie; Patricia  Limousin; Ludvic Zrinzo; Alexander L. Green; Tipu Aziz; Peter Brown

doi:10.1016/j.expneurol.2015.12.004

Subcortical evoked activity and motor enhancement in Parkinson's disease.

Anam Anzak, Huiling Tan, Alek Pogosyan, Sadaquate Khan, Shazia Javed, Steven S. Gill, Ashkan Keyoumars, Harith Akram, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Alexander L. Green, Tipu Aziz, Peter Brown (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Enhancements in motor performance have been demonstrated in response to intense stimuli both in healthy subjects and in the form of 'paradoxical kinesis' in patients with Parkinson's disease. Here we identify a mid-latency evoked potential in local field potential recordings from the region of the subthalamic nucleus, which scales in amplitude with both the intensity of the stimulus delivered and corresponding enhancements in biomechanical measures of maximal handgrips, independent of the dopaminergic state of our subjects with Parkinson's disease. Recordings of a similar evoked potential in the related pedunculopontine nucleus - a key component of the reticular activating system - provide support for this neural signature in the subthalmic nucleus being a novel correlate of ascending arousal, propagated from the reticular activating system to exert an 'energizing' influence on motor circuitry. Future manipulation of this system linking arousal and motor performance may provide a novel approach for the non-dopaminergic enhancement of motor performance in patients with hypokinetic disorders such as Parkinson's disease.

Original language	English
Pages (from-to)	19-26
Number of pages	8
Journal	Experimental Neurology
Volume	277
Early online date	11 Dec 2015
DOIs	https://doi.org/10.1016/j.expneurol.2015.12.004
Publication status	Published - 1 Mar 2016

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10.1016/j.expneurol.2015.12.004

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title = "Subcortical evoked activity and motor enhancement in Parkinson's disease.",

abstract = "Enhancements in motor performance have been demonstrated in response to intense stimuli both in healthy subjects and in the form of 'paradoxical kinesis' in patients with Parkinson's disease. Here we identify a mid-latency evoked potential in local field potential recordings from the region of the subthalamic nucleus, which scales in amplitude with both the intensity of the stimulus delivered and corresponding enhancements in biomechanical measures of maximal handgrips, independent of the dopaminergic state of our subjects with Parkinson's disease. Recordings of a similar evoked potential in the related pedunculopontine nucleus - a key component of the reticular activating system - provide support for this neural signature in the subthalmic nucleus being a novel correlate of ascending arousal, propagated from the reticular activating system to exert an 'energizing' influence on motor circuitry. Future manipulation of this system linking arousal and motor performance may provide a novel approach for the non-dopaminergic enhancement of motor performance in patients with hypokinetic disorders such as Parkinson's disease.",

author = "Anam Anzak and Huiling Tan and Alek Pogosyan and Sadaquate Khan and Shazia Javed and Gill, {Steven S.} and Ashkan Keyoumars and Harith Akram and Thomas Foltynie and Patricia Limousin and Ludvic Zrinzo and Green, {Alexander L.} and Tipu Aziz and Peter Brown",

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T1 - Subcortical evoked activity and motor enhancement in Parkinson's disease.

AU - Anzak, Anam

AU - Tan, Huiling

AU - Pogosyan, Alek

AU - Khan, Sadaquate

AU - Javed, Shazia

AU - Gill, Steven S.

AU - Keyoumars, Ashkan

AU - Akram, Harith

AU - Foltynie, Thomas

AU - Limousin, Patricia

AU - Zrinzo, Ludvic

AU - Green, Alexander L.

AU - Aziz, Tipu

AU - Brown, Peter

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Enhancements in motor performance have been demonstrated in response to intense stimuli both in healthy subjects and in the form of 'paradoxical kinesis' in patients with Parkinson's disease. Here we identify a mid-latency evoked potential in local field potential recordings from the region of the subthalamic nucleus, which scales in amplitude with both the intensity of the stimulus delivered and corresponding enhancements in biomechanical measures of maximal handgrips, independent of the dopaminergic state of our subjects with Parkinson's disease. Recordings of a similar evoked potential in the related pedunculopontine nucleus - a key component of the reticular activating system - provide support for this neural signature in the subthalmic nucleus being a novel correlate of ascending arousal, propagated from the reticular activating system to exert an 'energizing' influence on motor circuitry. Future manipulation of this system linking arousal and motor performance may provide a novel approach for the non-dopaminergic enhancement of motor performance in patients with hypokinetic disorders such as Parkinson's disease.

AB - Enhancements in motor performance have been demonstrated in response to intense stimuli both in healthy subjects and in the form of 'paradoxical kinesis' in patients with Parkinson's disease. Here we identify a mid-latency evoked potential in local field potential recordings from the region of the subthalamic nucleus, which scales in amplitude with both the intensity of the stimulus delivered and corresponding enhancements in biomechanical measures of maximal handgrips, independent of the dopaminergic state of our subjects with Parkinson's disease. Recordings of a similar evoked potential in the related pedunculopontine nucleus - a key component of the reticular activating system - provide support for this neural signature in the subthalmic nucleus being a novel correlate of ascending arousal, propagated from the reticular activating system to exert an 'energizing' influence on motor circuitry. Future manipulation of this system linking arousal and motor performance may provide a novel approach for the non-dopaminergic enhancement of motor performance in patients with hypokinetic disorders such as Parkinson's disease.

UR - https://europepmc.org/articles/PMC4767325

U2 - 10.1016/j.expneurol.2015.12.004

DO - 10.1016/j.expneurol.2015.12.004

M3 - Article

C2 - 26687971

SN - 0014-4886

VL - 277

SP - 19

EP - 26

JO - Experimental Neurology

JF - Experimental Neurology

ER -

Subcortical evoked activity and motor enhancement in Parkinson's disease.

Abstract

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