Subsequent Event Risk in Individuals with Established Coronary Heart Disease

Design and Rationale of the GENIUS-CHD Consortium

Riyaz Patel (Lead / Corresponding author), Vinicius Tragante, Amand F. Schmidt, Raymond O. McCubrey, Michael V. Holmes, Laurence J. Howe, Kenan Direk, Axel Åkerblom, Karin Leander, Salim S. Virani, Karol A. Kaminski, Jochen D. Muehlschlegel, Hooman Allayee, Peter Almgren, Maris Alver, Ekaterina V. Baranova, Hassan Behlouli, Bram Boeckx, Peter S. Braund, Lutz P. Breitling & 161 others Graciela Delgado, Nubia E. Duarte, Marie-Pierre Dubé, Line Dufresne, Niclas Eriksson, Luisa Foco, Markus Scholz, Crystel M. Gijsberts, Charlotte Glinge, Yan Gong, Jaana Hartiala, Mahyar Heydarpour, Jaroslav A. Hubacek, Marcus Kleber, Daniel Kofink, Salma Kotti, Pekka Kuukasjärvi, Vei-Vei Lee, Andreas Leiherer, Petra A. Lenzini, Daniel Levin, Leo-Pekka Lyytikäinen, Nicola Martinelli, Ute Mons, Christopher P. Nelson, Kjell Nikus, Anna P. Pilbrow, Rafal Ploski, Yan V. Sun, Michael W. T. Tanck, W. H. Wilson Tang, Stella Trompet, Sander W. van der Laan, Jessica Van Setten, Ragnar O. Vilmundarson, Chiara Viviani Anselmi, Efthymia Vlachopoulou, Lawien Al Ali, Eric Boerwinkle, Carlo Briguori, John F. Carlquist, Kathryn F. Carruthers, Gavino Casu, John Deanfield, Panos Deloukas, Frank Dudbridge, Thomas Engström, Natalie Fitzpatrick, Kim Fox, Bruna Gigante, Stefan James, Marja-Liisa Lokki, Paulo A. Lotufo, Nicola Marziliano, Ify R. Mordi, Joseph B. Muhlestein, Christopher Newton-Cheh, Jan Pitha, Christoph H. Saely, Ayman Samman-Tahhan, Pratik B. Sandesara, Andrej Teren, Adam Timmis, Frans Van de Werf, Els Wauters, Arthur A. M. Wilde, Ian Ford, David J. Stott, Ale Algra, Maria G. Andreassi, Diego Ardissino, Benoit J. Arsenault, Christie M. Ballantyne, Thomas O. Bergmeijer, Connie R. Bezzina, Simon C. Body, Eric H. Boersma, Peter Bogaty, Michiel Bots, Hermann Brenner, Jasper J. Brugts, Ralph Burkhardt, Clara Carpeggiani, Gianluigi Condorelli, Rhonda M. Cooper-DeHoff, Sharon Cresci, Nicolas Danchin, Ulf de Faire, Robert N. Doughty, Heinz Drexel, James C. Engert, Keith A. A. Fox, Domenico Girelli, Diederick E. Grobbee, Emil Hagström, Stanley L. Hazen, Claes Held, Harry Hemingway, Imo E. Hoefer, G. Kees Hovingh, Reza Jabbari, Julie A. Johnson, J. Wouter Jukema, Marcin P. Kaczor, Mika Kähönen, Jiri Kettner, Marek Kiliszek, Olaf H. Klungel, Bo Lagerqvist, Diether Lambrechts, Jari O. Laurikka, Terho Lehtimäki, Daniel Lindholm, B. K. Mahmoodi, Anke H. Maitland-van der Zee, Ruth McPherson, Olle Melander, Andres Metspalu, Anna Niemcunowicz-Janica, Oliviero Olivieri, Grzegorz Opolski, Colin N. Palmer, Gerard Pasterkamp, Carl J. Pepine, Alexandre C. Pereira, Louise Pilote, Arshed A. Quyyumi, A. Mark Richards, Marek Sanak, Agneta Siegbahn, Tabassome Simon, Juha Sinisalo, J. Gustav Smith, John A. Spertus, Steen Stender, Alexandre F. R. Stewart, Wojciech Szczeklik, Anna Szpakowicz, Jean-Claude Tardif, Jurriën M Ten Berg, Jacob Tfelt-Hansen, George Thanassoulis, Joachim Thiery, Christian Torp-Pedersen, Yolanda van der Graaf, Frank L. J. Visseren, Johannes Waltenberger, Peter E. Weeke, Pim Van der Harst, Chim C. Lang, Naveed Sattar, Vicky A. Cameron, Jeffrey L. Anderson, James M. Brophy, Guillaume Paré, Benjamin D. Horne, Winfried März, Lars Wallentin, Nilesh J. Samani, Aroon D. Hingorani, Folkert W. Asselbergs

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Abstract

Background: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.

Methods: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.

Results: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.

Conclusions: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.

Original languageEnglish
Article numbere002470
Pages (from-to)145-160
Number of pages16
JournalCirculation: Genomic and Precision Medicine
Volume12
Issue number4
Early online date21 Mar 2019
DOIs
Publication statusPublished - Apr 2019

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Coronary Disease
Sex Ratio
Acute Coronary Syndrome
Secondary Prevention
Biomarkers
Smoking
Myocardial Infarction
Research Personnel
Pharmaceutical Preparations

Keywords

  • coronary artery disease
  • genetics
  • association studies
  • residual risk
  • secondary prevention
  • recurrent event
  • myocardial infarction
  • prognosis

Cite this

Patel, R., Tragante, V., Schmidt, A. F., McCubrey, R. O., Holmes, M. V., Howe, L. J., ... Asselbergs, F. W. (2019). Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium. Circulation: Genomic and Precision Medicine, 12(4), 145-160. [e002470]. https://doi.org/10.1161/CIRCGEN.119.002470
Patel, Riyaz ; Tragante, Vinicius ; Schmidt, Amand F. ; McCubrey, Raymond O. ; Holmes, Michael V. ; Howe, Laurence J. ; Direk, Kenan ; Åkerblom, Axel ; Leander, Karin ; Virani, Salim S. ; Kaminski, Karol A. ; Muehlschlegel, Jochen D. ; Allayee, Hooman ; Almgren, Peter ; Alver, Maris ; Baranova, Ekaterina V. ; Behlouli, Hassan ; Boeckx, Bram ; Braund, Peter S. ; Breitling, Lutz P. ; Delgado, Graciela ; Duarte, Nubia E. ; Dubé, Marie-Pierre ; Dufresne, Line ; Eriksson, Niclas ; Foco, Luisa ; Scholz, Markus ; Gijsberts, Crystel M. ; Glinge, Charlotte ; Gong, Yan ; Hartiala, Jaana ; Heydarpour, Mahyar ; Hubacek, Jaroslav A. ; Kleber, Marcus ; Kofink, Daniel ; Kotti, Salma ; Kuukasjärvi, Pekka ; Lee, Vei-Vei ; Leiherer, Andreas ; Lenzini, Petra A. ; Levin, Daniel ; Lyytikäinen, Leo-Pekka ; Martinelli, Nicola ; Mons, Ute ; Nelson, Christopher P. ; Nikus, Kjell ; Pilbrow, Anna P. ; Ploski, Rafal ; Sun, Yan V. ; Tanck, Michael W. T. ; Tang, W. H. Wilson ; Trompet, Stella ; van der Laan, Sander W. ; Van Setten, Jessica ; Vilmundarson, Ragnar O. ; Viviani Anselmi, Chiara ; Vlachopoulou, Efthymia ; Al Ali, Lawien ; Boerwinkle, Eric ; Briguori, Carlo ; Carlquist, John F. ; Carruthers, Kathryn F. ; Casu, Gavino ; Deanfield, John ; Deloukas, Panos ; Dudbridge, Frank ; Engström, Thomas ; Fitzpatrick, Natalie ; Fox, Kim ; Gigante, Bruna ; James, Stefan ; Lokki, Marja-Liisa ; Lotufo, Paulo A. ; Marziliano, Nicola ; Mordi, Ify R. ; Muhlestein, Joseph B. ; Newton-Cheh, Christopher ; Pitha, Jan ; Saely, Christoph H. ; Samman-Tahhan, Ayman ; Sandesara, Pratik B. ; Teren, Andrej ; Timmis, Adam ; Van de Werf, Frans ; Wauters, Els ; Wilde, Arthur A. M. ; Ford, Ian ; Stott, David J. ; Algra, Ale ; Andreassi, Maria G. ; Ardissino, Diego ; Arsenault, Benoit J. ; Ballantyne, Christie M. ; Bergmeijer, Thomas O. ; Bezzina, Connie R. ; Body, Simon C. ; Boersma, Eric H. ; Bogaty, Peter ; Bots, Michiel ; Brenner, Hermann ; Brugts, Jasper J. ; Burkhardt, Ralph ; Carpeggiani, Clara ; Condorelli, Gianluigi ; Cooper-DeHoff, Rhonda M. ; Cresci, Sharon ; Danchin, Nicolas ; de Faire, Ulf ; Doughty, Robert N. ; Drexel, Heinz ; Engert, James C. ; Fox, Keith A. A. ; Girelli, Domenico ; Grobbee, Diederick E. ; Hagström, Emil ; Hazen, Stanley L. ; Held, Claes ; Hemingway, Harry ; Hoefer, Imo E. ; Hovingh, G. Kees ; Jabbari, Reza ; Johnson, Julie A. ; Jukema, J. Wouter ; Kaczor, Marcin P. ; Kähönen, Mika ; Kettner, Jiri ; Kiliszek, Marek ; Klungel, Olaf H. ; Lagerqvist, Bo ; Lambrechts, Diether ; Laurikka, Jari O. ; Lehtimäki, Terho ; Lindholm, Daniel ; Mahmoodi, B. K. ; Maitland-van der Zee, Anke H. ; McPherson, Ruth ; Melander, Olle ; Metspalu, Andres ; Niemcunowicz-Janica, Anna ; Olivieri, Oliviero ; Opolski, Grzegorz ; Palmer, Colin N. ; Pasterkamp, Gerard ; Pepine, Carl J. ; Pereira, Alexandre C. ; Pilote, Louise ; Quyyumi, Arshed A. ; Richards, A. Mark ; Sanak, Marek ; Siegbahn, Agneta ; Simon, Tabassome ; Sinisalo, Juha ; Smith, J. Gustav ; Spertus, John A. ; Stender, Steen ; Stewart, Alexandre F. R. ; Szczeklik, Wojciech ; Szpakowicz, Anna ; Tardif, Jean-Claude ; Ten Berg, Jurriën M ; Tfelt-Hansen, Jacob ; Thanassoulis, George ; Thiery, Joachim ; Torp-Pedersen, Christian ; van der Graaf, Yolanda ; Visseren, Frank L. J. ; Waltenberger, Johannes ; Weeke, Peter E. ; Van der Harst, Pim ; Lang, Chim C. ; Sattar, Naveed ; Cameron, Vicky A. ; Anderson, Jeffrey L. ; Brophy, James M. ; Paré, Guillaume ; Horne, Benjamin D. ; März, Winfried ; Wallentin, Lars ; Samani, Nilesh J. ; Hingorani, Aroon D. ; Asselbergs, Folkert W. / Subsequent Event Risk in Individuals with Established Coronary Heart Disease : Design and Rationale of the GENIUS-CHD Consortium. In: Circulation: Genomic and Precision Medicine. 2019 ; Vol. 12, No. 4. pp. 145-160.
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title = "Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium",
abstract = "Background: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.Methods: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.Results: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38{\%}-100{\%}), mostly male (44{\%}-91{\%}) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95{\%} CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95{\%} CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95{\%} CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.Conclusions: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.",
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year = "2019",
month = "4",
doi = "10.1161/CIRCGEN.119.002470",
language = "English",
volume = "12",
pages = "145--160",
journal = "Circulation: Genomic and Precision Medicine",
issn = "2574-8300",
publisher = "Lippincott, Williams & Wilkins",
number = "4",

}

Patel, R, Tragante, V, Schmidt, AF, McCubrey, RO, Holmes, MV, Howe, LJ, Direk, K, Åkerblom, A, Leander, K, Virani, SS, Kaminski, KA, Muehlschlegel, JD, Allayee, H, Almgren, P, Alver, M, Baranova, EV, Behlouli, H, Boeckx, B, Braund, PS, Breitling, LP, Delgado, G, Duarte, NE, Dubé, M-P, Dufresne, L, Eriksson, N, Foco, L, Scholz, M, Gijsberts, CM, Glinge, C, Gong, Y, Hartiala, J, Heydarpour, M, Hubacek, JA, Kleber, M, Kofink, D, Kotti, S, Kuukasjärvi, P, Lee, V-V, Leiherer, A, Lenzini, PA, Levin, D, Lyytikäinen, L-P, Martinelli, N, Mons, U, Nelson, CP, Nikus, K, Pilbrow, AP, Ploski, R, Sun, YV, Tanck, MWT, Tang, WHW, Trompet, S, van der Laan, SW, Van Setten, J, Vilmundarson, RO, Viviani Anselmi, C, Vlachopoulou, E, Al Ali, L, Boerwinkle, E, Briguori, C, Carlquist, JF, Carruthers, KF, Casu, G, Deanfield, J, Deloukas, P, Dudbridge, F, Engström, T, Fitzpatrick, N, Fox, K, Gigante, B, James, S, Lokki, M-L, Lotufo, PA, Marziliano, N, Mordi, IR, Muhlestein, JB, Newton-Cheh, C, Pitha, J, Saely, CH, Samman-Tahhan, A, Sandesara, PB, Teren, A, Timmis, A, Van de Werf, F, Wauters, E, Wilde, AAM, Ford, I, Stott, DJ, Algra, A, Andreassi, MG, Ardissino, D, Arsenault, BJ, Ballantyne, CM, Bergmeijer, TO, Bezzina, CR, Body, SC, Boersma, EH, Bogaty, P, Bots, M, Brenner, H, Brugts, JJ, Burkhardt, R, Carpeggiani, C, Condorelli, G, Cooper-DeHoff, RM, Cresci, S, Danchin, N, de Faire, U, Doughty, RN, Drexel, H, Engert, JC, Fox, KAA, Girelli, D, Grobbee, DE, Hagström, E, Hazen, SL, Held, C, Hemingway, H, Hoefer, IE, Hovingh, GK, Jabbari, R, Johnson, JA, Jukema, JW, Kaczor, MP, Kähönen, M, Kettner, J, Kiliszek, M, Klungel, OH, Lagerqvist, B, Lambrechts, D, Laurikka, JO, Lehtimäki, T, Lindholm, D, Mahmoodi, BK, Maitland-van der Zee, AH, McPherson, R, Melander, O, Metspalu, A, Niemcunowicz-Janica, A, Olivieri, O, Opolski, G, Palmer, CN, Pasterkamp, G, Pepine, CJ, Pereira, AC, Pilote, L, Quyyumi, AA, Richards, AM, Sanak, M, Siegbahn, A, Simon, T, Sinisalo, J, Smith, JG, Spertus, JA, Stender, S, Stewart, AFR, Szczeklik, W, Szpakowicz, A, Tardif, J-C, Ten Berg, JM, Tfelt-Hansen, J, Thanassoulis, G, Thiery, J, Torp-Pedersen, C, van der Graaf, Y, Visseren, FLJ, Waltenberger, J, Weeke, PE, Van der Harst, P, Lang, CC, Sattar, N, Cameron, VA, Anderson, JL, Brophy, JM, Paré, G, Horne, BD, März, W, Wallentin, L, Samani, NJ, Hingorani, AD & Asselbergs, FW 2019, 'Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium', Circulation: Genomic and Precision Medicine, vol. 12, no. 4, e002470, pp. 145-160. https://doi.org/10.1161/CIRCGEN.119.002470

Subsequent Event Risk in Individuals with Established Coronary Heart Disease : Design and Rationale of the GENIUS-CHD Consortium. / Patel, Riyaz (Lead / Corresponding author); Tragante, Vinicius; Schmidt, Amand F.; McCubrey, Raymond O.; Holmes, Michael V.; Howe, Laurence J.; Direk, Kenan; Åkerblom, Axel; Leander, Karin; Virani, Salim S.; Kaminski, Karol A.; Muehlschlegel, Jochen D.; Allayee, Hooman; Almgren, Peter; Alver, Maris; Baranova, Ekaterina V.; Behlouli, Hassan; Boeckx, Bram; Braund, Peter S.; Breitling, Lutz P.; Delgado, Graciela; Duarte, Nubia E.; Dubé, Marie-Pierre; Dufresne, Line; Eriksson, Niclas; Foco, Luisa; Scholz, Markus; Gijsberts, Crystel M.; Glinge, Charlotte; Gong, Yan; Hartiala, Jaana; Heydarpour, Mahyar; Hubacek, Jaroslav A.; Kleber, Marcus; Kofink, Daniel; Kotti, Salma; Kuukasjärvi, Pekka; Lee, Vei-Vei; Leiherer, Andreas; Lenzini, Petra A.; Levin, Daniel; Lyytikäinen, Leo-Pekka; Martinelli, Nicola; Mons, Ute; Nelson, Christopher P.; Nikus, Kjell; Pilbrow, Anna P.; Ploski, Rafal; Sun, Yan V.; Tanck, Michael W. T.; Tang, W. H. Wilson; Trompet, Stella; van der Laan, Sander W.; Van Setten, Jessica; Vilmundarson, Ragnar O.; Viviani Anselmi, Chiara; Vlachopoulou, Efthymia; Al Ali, Lawien; Boerwinkle, Eric; Briguori, Carlo; Carlquist, John F.; Carruthers, Kathryn F.; Casu, Gavino; Deanfield, John; Deloukas, Panos; Dudbridge, Frank; Engström, Thomas; Fitzpatrick, Natalie; Fox, Kim; Gigante, Bruna; James, Stefan; Lokki, Marja-Liisa; Lotufo, Paulo A.; Marziliano, Nicola; Mordi, Ify R.; Muhlestein, Joseph B.; Newton-Cheh, Christopher; Pitha, Jan; Saely, Christoph H.; Samman-Tahhan, Ayman; Sandesara, Pratik B.; Teren, Andrej; Timmis, Adam; Van de Werf, Frans; Wauters, Els; Wilde, Arthur A. M.; Ford, Ian; Stott, David J.; Algra, Ale; Andreassi, Maria G.; Ardissino, Diego; Arsenault, Benoit J.; Ballantyne, Christie M.; Bergmeijer, Thomas O.; Bezzina, Connie R.; Body, Simon C.; Boersma, Eric H.; Bogaty, Peter; Bots, Michiel; Brenner, Hermann; Brugts, Jasper J.; Burkhardt, Ralph; Carpeggiani, Clara; Condorelli, Gianluigi; Cooper-DeHoff, Rhonda M.; Cresci, Sharon; Danchin, Nicolas; de Faire, Ulf; Doughty, Robert N.; Drexel, Heinz; Engert, James C.; Fox, Keith A. A.; Girelli, Domenico; Grobbee, Diederick E.; Hagström, Emil; Hazen, Stanley L.; Held, Claes; Hemingway, Harry; Hoefer, Imo E.; Hovingh, G. Kees; Jabbari, Reza; Johnson, Julie A.; Jukema, J. Wouter; Kaczor, Marcin P.; Kähönen, Mika; Kettner, Jiri; Kiliszek, Marek; Klungel, Olaf H.; Lagerqvist, Bo; Lambrechts, Diether; Laurikka, Jari O.; Lehtimäki, Terho; Lindholm, Daniel; Mahmoodi, B. K.; Maitland-van der Zee, Anke H.; McPherson, Ruth; Melander, Olle; Metspalu, Andres; Niemcunowicz-Janica, Anna; Olivieri, Oliviero; Opolski, Grzegorz; Palmer, Colin N.; Pasterkamp, Gerard; Pepine, Carl J.; Pereira, Alexandre C.; Pilote, Louise; Quyyumi, Arshed A.; Richards, A. Mark; Sanak, Marek; Siegbahn, Agneta; Simon, Tabassome; Sinisalo, Juha; Smith, J. Gustav; Spertus, John A.; Stender, Steen; Stewart, Alexandre F. R.; Szczeklik, Wojciech; Szpakowicz, Anna; Tardif, Jean-Claude; Ten Berg, Jurriën M; Tfelt-Hansen, Jacob; Thanassoulis, George; Thiery, Joachim; Torp-Pedersen, Christian; van der Graaf, Yolanda; Visseren, Frank L. J.; Waltenberger, Johannes; Weeke, Peter E.; Van der Harst, Pim; Lang, Chim C.; Sattar, Naveed; Cameron, Vicky A.; Anderson, Jeffrey L.; Brophy, James M.; Paré, Guillaume; Horne, Benjamin D.; März, Winfried; Wallentin, Lars; Samani, Nilesh J.; Hingorani, Aroon D.; Asselbergs, Folkert W.

In: Circulation: Genomic and Precision Medicine, Vol. 12, No. 4, e002470, 04.2019, p. 145-160.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Subsequent Event Risk in Individuals with Established Coronary Heart Disease

T2 - Design and Rationale of the GENIUS-CHD Consortium

AU - Patel, Riyaz

AU - Tragante, Vinicius

AU - Schmidt, Amand F.

AU - McCubrey, Raymond O.

AU - Holmes, Michael V.

AU - Howe, Laurence J.

AU - Direk, Kenan

AU - Åkerblom, Axel

AU - Leander, Karin

AU - Virani, Salim S.

AU - Kaminski, Karol A.

AU - Muehlschlegel, Jochen D.

AU - Allayee, Hooman

AU - Almgren, Peter

AU - Alver, Maris

AU - Baranova, Ekaterina V.

AU - Behlouli, Hassan

AU - Boeckx, Bram

AU - Braund, Peter S.

AU - Breitling, Lutz P.

AU - Delgado, Graciela

AU - Duarte, Nubia E.

AU - Dubé, Marie-Pierre

AU - Dufresne, Line

AU - Eriksson, Niclas

AU - Foco, Luisa

AU - Scholz, Markus

AU - Gijsberts, Crystel M.

AU - Glinge, Charlotte

AU - Gong, Yan

AU - Hartiala, Jaana

AU - Heydarpour, Mahyar

AU - Hubacek, Jaroslav A.

AU - Kleber, Marcus

AU - Kofink, Daniel

AU - Kotti, Salma

AU - Kuukasjärvi, Pekka

AU - Lee, Vei-Vei

AU - Leiherer, Andreas

AU - Lenzini, Petra A.

AU - Levin, Daniel

AU - Lyytikäinen, Leo-Pekka

AU - Martinelli, Nicola

AU - Mons, Ute

AU - Nelson, Christopher P.

AU - Nikus, Kjell

AU - Pilbrow, Anna P.

AU - Ploski, Rafal

AU - Sun, Yan V.

AU - Tanck, Michael W. T.

AU - Tang, W. H. Wilson

AU - Trompet, Stella

AU - van der Laan, Sander W.

AU - Van Setten, Jessica

AU - Vilmundarson, Ragnar O.

AU - Viviani Anselmi, Chiara

AU - Vlachopoulou, Efthymia

AU - Al Ali, Lawien

AU - Boerwinkle, Eric

AU - Briguori, Carlo

AU - Carlquist, John F.

AU - Carruthers, Kathryn F.

AU - Casu, Gavino

AU - Deanfield, John

AU - Deloukas, Panos

AU - Dudbridge, Frank

AU - Engström, Thomas

AU - Fitzpatrick, Natalie

AU - Fox, Kim

AU - Gigante, Bruna

AU - James, Stefan

AU - Lokki, Marja-Liisa

AU - Lotufo, Paulo A.

AU - Marziliano, Nicola

AU - Mordi, Ify R.

AU - Muhlestein, Joseph B.

AU - Newton-Cheh, Christopher

AU - Pitha, Jan

AU - Saely, Christoph H.

AU - Samman-Tahhan, Ayman

AU - Sandesara, Pratik B.

AU - Teren, Andrej

AU - Timmis, Adam

AU - Van de Werf, Frans

AU - Wauters, Els

AU - Wilde, Arthur A. M.

AU - Ford, Ian

AU - Stott, David J.

AU - Algra, Ale

AU - Andreassi, Maria G.

AU - Ardissino, Diego

AU - Arsenault, Benoit J.

AU - Ballantyne, Christie M.

AU - Bergmeijer, Thomas O.

AU - Bezzina, Connie R.

AU - Body, Simon C.

AU - Boersma, Eric H.

AU - Bogaty, Peter

AU - Bots, Michiel

AU - Brenner, Hermann

AU - Brugts, Jasper J.

AU - Burkhardt, Ralph

AU - Carpeggiani, Clara

AU - Condorelli, Gianluigi

AU - Cooper-DeHoff, Rhonda M.

AU - Cresci, Sharon

AU - Danchin, Nicolas

AU - de Faire, Ulf

AU - Doughty, Robert N.

AU - Drexel, Heinz

AU - Engert, James C.

AU - Fox, Keith A. A.

AU - Girelli, Domenico

AU - Grobbee, Diederick E.

AU - Hagström, Emil

AU - Hazen, Stanley L.

AU - Held, Claes

AU - Hemingway, Harry

AU - Hoefer, Imo E.

AU - Hovingh, G. Kees

AU - Jabbari, Reza

AU - Johnson, Julie A.

AU - Jukema, J. Wouter

AU - Kaczor, Marcin P.

AU - Kähönen, Mika

AU - Kettner, Jiri

AU - Kiliszek, Marek

AU - Klungel, Olaf H.

AU - Lagerqvist, Bo

AU - Lambrechts, Diether

AU - Laurikka, Jari O.

AU - Lehtimäki, Terho

AU - Lindholm, Daniel

AU - Mahmoodi, B. K.

AU - Maitland-van der Zee, Anke H.

AU - McPherson, Ruth

AU - Melander, Olle

AU - Metspalu, Andres

AU - Niemcunowicz-Janica, Anna

AU - Olivieri, Oliviero

AU - Opolski, Grzegorz

AU - Palmer, Colin N.

AU - Pasterkamp, Gerard

AU - Pepine, Carl J.

AU - Pereira, Alexandre C.

AU - Pilote, Louise

AU - Quyyumi, Arshed A.

AU - Richards, A. Mark

AU - Sanak, Marek

AU - Siegbahn, Agneta

AU - Simon, Tabassome

AU - Sinisalo, Juha

AU - Smith, J. Gustav

AU - Spertus, John A.

AU - Stender, Steen

AU - Stewart, Alexandre F. R.

AU - Szczeklik, Wojciech

AU - Szpakowicz, Anna

AU - Tardif, Jean-Claude

AU - Ten Berg, Jurriën M

AU - Tfelt-Hansen, Jacob

AU - Thanassoulis, George

AU - Thiery, Joachim

AU - Torp-Pedersen, Christian

AU - van der Graaf, Yolanda

AU - Visseren, Frank L. J.

AU - Waltenberger, Johannes

AU - Weeke, Peter E.

AU - Van der Harst, Pim

AU - Lang, Chim C.

AU - Sattar, Naveed

AU - Cameron, Vicky A.

AU - Anderson, Jeffrey L.

AU - Brophy, James M.

AU - Paré, Guillaume

AU - Horne, Benjamin D.

AU - März, Winfried

AU - Wallentin, Lars

AU - Samani, Nilesh J.

AU - Hingorani, Aroon D.

AU - Asselbergs, Folkert W.

PY - 2019/4

Y1 - 2019/4

N2 - Background: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.Methods: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.Results: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.Conclusions: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.

AB - Background: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.Methods: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.Results: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.Conclusions: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.

KW - coronary artery disease

KW - genetics

KW - association studies

KW - residual risk

KW - secondary prevention

KW - recurrent event

KW - myocardial infarction

KW - prognosis

UR - http://www.scopus.com/inward/record.url?scp=85069626441&partnerID=8YFLogxK

U2 - 10.1161/CIRCGEN.119.002470

DO - 10.1161/CIRCGEN.119.002470

M3 - Article

VL - 12

SP - 145

EP - 160

JO - Circulation: Genomic and Precision Medicine

JF - Circulation: Genomic and Precision Medicine

SN - 2574-8300

IS - 4

M1 - e002470

ER -