TY - JOUR
T1 - Substituted Naphthols
T2 - Preparations, Applications, and Reactions
AU - Vargas, Jorge Andrés Mora
AU - Day, David P.
AU - Burtoloso, Antonio C. B.
N1 - Funding Information:
DPD is grateful for funding and support through a FAPESP post‐doctoral scholarship (2019/05002‐8). JAMV wishes to thank Universidad Santiago de Cali for the fellowship (Convocatoria interna DGI No. 016‐2019: Joven investigador santiaguino).
Publisher Copyright:
© 2020 Wiley-VCH GmbH
PY - 2021/2/5
Y1 - 2021/2/5
N2 - Substituted naphthols (SNs) are an important class of chemical compounds present in many natural and synthetic products with biological and pharmaceutical activities. Moreover, the naphthol skeleton has been employed as a starting material for the development of drug molecules and natural products. Thus, different synthetic methods to access naphthol cores have been reported using diverse starting materials and chemical strategies. This review article describes literature on synthetic methodologies of substituted naphthols synthesized from alkynes, sulfur ylides, diazo substrates, alkenes/cyclopropenes, ketones/oxanorbenes/furans, amongst other key reactants.
AB - Substituted naphthols (SNs) are an important class of chemical compounds present in many natural and synthetic products with biological and pharmaceutical activities. Moreover, the naphthol skeleton has been employed as a starting material for the development of drug molecules and natural products. Thus, different synthetic methods to access naphthol cores have been reported using diverse starting materials and chemical strategies. This review article describes literature on synthetic methodologies of substituted naphthols synthesized from alkynes, sulfur ylides, diazo substrates, alkenes/cyclopropenes, ketones/oxanorbenes/furans, amongst other key reactants.
KW - Cyclization
KW - C–H activations
KW - Insertion
KW - Ring construction
KW - Substituted naphthols
UR - http://www.scopus.com/inward/record.url?scp=85096656705&partnerID=8YFLogxK
U2 - 10.1002/ejoc.202001132
DO - 10.1002/ejoc.202001132
M3 - Review article
AN - SCOPUS:85096656705
SN - 1434-193X
VL - 2021
SP - 741
EP - 756
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
IS - 5
ER -