Substituted Naphthols: Preparations, Applications, and Reactions

Jorge Andrés Mora Vargas, David P. Day, Antonio C. B. Burtoloso (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

Substituted naphthols (SNs) are an important class of chemical compounds present in many natural and synthetic products with biological and pharmaceutical activities. Moreover, the naphthol skeleton has been employed as a starting material for the development of drug molecules and natural products. Thus, different synthetic methods to access naphthol cores have been reported using diverse starting materials and chemical strategies. This review article describes literature on synthetic methodologies of substituted naphthols synthesized from alkynes, sulfur ylides, diazo substrates, alkenes/cyclopropenes, ketones/oxanorbenes/furans, amongst other key reactants.

Original languageEnglish
Pages (from-to)741-756
Number of pages16
JournalEuropean Journal of Organic Chemistry
Volume2021
Issue number5
Early online date14 Oct 2020
DOIs
Publication statusPublished - 5 Feb 2021

Keywords

  • Cyclization
  • C–H activations
  • Insertion
  • Ring construction
  • Substituted naphthols

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