Substituted Naphthols: Preparations, Applications, and Reactions

Jorge Andrés Mora Vargas; David P. Day; Antonio C. B. Burtoloso

doi:10.1002/ejoc.202001132

Substituted Naphthols: Preparations, Applications, and Reactions

Jorge Andrés Mora Vargas
, David P. Day
, Antonio C. B. Burtoloso (Lead / Corresponding author)

Drug Discovery Unit

Research output: Contribution to journal › Review article › peer-review

37 Citations (Scopus)

Abstract

Substituted naphthols (SNs) are an important class of chemical compounds present in many natural and synthetic products with biological and pharmaceutical activities. Moreover, the naphthol skeleton has been employed as a starting material for the development of drug molecules and natural products. Thus, different synthetic methods to access naphthol cores have been reported using diverse starting materials and chemical strategies. This review article describes literature on synthetic methodologies of substituted naphthols synthesized from alkynes, sulfur ylides, diazo substrates, alkenes/cyclopropenes, ketones/oxanorbenes/furans, amongst other key reactants.

Original language	English
Pages (from-to)	741-756
Number of pages	16
Journal	European Journal of Organic Chemistry
Volume	2021
Issue number	5
Early online date	14 Oct 2020
DOIs	https://doi.org/10.1002/ejoc.202001132
Publication status	Published - 5 Feb 2021

Keywords

Cyclization
C–H activations
Insertion
Ring construction
Substituted naphthols

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry

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10.1002/ejoc.202001132

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title = "Substituted Naphthols: Preparations, Applications, and Reactions",

abstract = "Substituted naphthols (SNs) are an important class of chemical compounds present in many natural and synthetic products with biological and pharmaceutical activities. Moreover, the naphthol skeleton has been employed as a starting material for the development of drug molecules and natural products. Thus, different synthetic methods to access naphthol cores have been reported using diverse starting materials and chemical strategies. This review article describes literature on synthetic methodologies of substituted naphthols synthesized from alkynes, sulfur ylides, diazo substrates, alkenes/cyclopropenes, ketones/oxanorbenes/furans, amongst other key reactants.",

keywords = "Cyclization, C–H activations, Insertion, Ring construction, Substituted naphthols",

author = "Vargas, \{Jorge Andr{\'e}s Mora\} and Day, \{David P.\} and Burtoloso, \{Antonio C. B.\}",

note = "Funding Information: DPD is grateful for funding and support through a FAPESP post‐doctoral scholarship (2019/05002‐8). JAMV wishes to thank Universidad Santiago de Cali for the fellowship (Convocatoria interna DGI No. 016‐2019: Joven investigador santiaguino). Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH",

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AU - Vargas, Jorge Andrés Mora

AU - Day, David P.

AU - Burtoloso, Antonio C. B.

N1 - Funding Information: DPD is grateful for funding and support through a FAPESP post‐doctoral scholarship (2019/05002‐8). JAMV wishes to thank Universidad Santiago de Cali for the fellowship (Convocatoria interna DGI No. 016‐2019: Joven investigador santiaguino). Publisher Copyright: © 2020 Wiley-VCH GmbH

PY - 2021/2/5

Y1 - 2021/2/5

N2 - Substituted naphthols (SNs) are an important class of chemical compounds present in many natural and synthetic products with biological and pharmaceutical activities. Moreover, the naphthol skeleton has been employed as a starting material for the development of drug molecules and natural products. Thus, different synthetic methods to access naphthol cores have been reported using diverse starting materials and chemical strategies. This review article describes literature on synthetic methodologies of substituted naphthols synthesized from alkynes, sulfur ylides, diazo substrates, alkenes/cyclopropenes, ketones/oxanorbenes/furans, amongst other key reactants.

AB - Substituted naphthols (SNs) are an important class of chemical compounds present in many natural and synthetic products with biological and pharmaceutical activities. Moreover, the naphthol skeleton has been employed as a starting material for the development of drug molecules and natural products. Thus, different synthetic methods to access naphthol cores have been reported using diverse starting materials and chemical strategies. This review article describes literature on synthetic methodologies of substituted naphthols synthesized from alkynes, sulfur ylides, diazo substrates, alkenes/cyclopropenes, ketones/oxanorbenes/furans, amongst other key reactants.

KW - Cyclization

KW - C–H activations

KW - Insertion

KW - Ring construction

KW - Substituted naphthols

UR - https://www.scopus.com/pages/publications/85096656705

U2 - 10.1002/ejoc.202001132

DO - 10.1002/ejoc.202001132

M3 - Review article

AN - SCOPUS:85096656705

SN - 1434-193X

VL - 2021

SP - 741

EP - 756

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 5

ER -

Substituted Naphthols: Preparations, Applications, and Reactions

Abstract

Keywords

ASJC Scopus subject areas

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