There is evidence to suggest that platelet activation occurs in Raynaud's syndrome. We evaluated the effect of prostacyclin (PGI2) a potent antiplatelet and vasodilator agent in 5 female patients with Raynaud's syndrome. Outpatient visits were made at weekly intervals for 4 weeks. At the first visit buffer solution (Wellcome Laboratories) was infused intravenously for 5 hrs, thereafter three five hr infusions of PGI2 at a peak dose of 10 ng/Kg/min were given. Six weeks after the infusions patients were reviewed. Symptomatic improvement, including healing of ischaemic ulcers, occurred in 4 out of 5 patients. Thermography confirmed an increase in hand temperature after PCI2. Subjective and objective improvement has persisted for at least 6 weeks after the last treatment.
|Number of pages||2|
|Journal||Thrombosis and Haemostasis|
|Publication status||Published - 1981|
Belch, J. J., Newman, P., Drury, J. K., Capell, H., Leiberman, P., James, W. B., Forbes, C. D., & Prentice, C. R. (1981). Successful treatment of Raynaud's Syndrome with prostacyclin. Thrombosis and Haemostasis, 45(3), 255-6. http://www.ncbi.nlm.nih.gov/pubmed/7025341