Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study

Sjors Verlaan (Lead / Corresponding author), Andrea B. Maier, Jürgen M. Bauer, Ivan Bautmans, Kirsten Brandt, Lorenzo M. Donini, Marcello Maggio, Marion E. T. McMurdo, Tony Mets, Chris Seal, Sander L. J. Wijers, Cornel Sieber, Yves Boirie, Tommy Cederholm

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Abstract

Background: Inadequate nutritional intake and altered response of aging muscles to anabolic stimuli from nutrients contribute to the development of sarcopenia. Nutritional interventions show inconsistent results in sarcopenic older adults, which might be influenced by their basal nutritional status.

Objective: To test if baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations and dietary protein intake influenced changes in muscle mass and function in older adults who received nutritional intervention.

Methods and Design: Post-hoc analysis was performed in the PROVIDE study that was a randomized controlled, double blind trial among 380 sarcopenic older adults. This study showed that those who received a vitamin D and leucine-enriched whey protein medical nutrition drink for 13 weeks gained more appendicular muscle mass (aMM), and improved lower-extremity function as assessed by the chair stand test compared with controls. To define low and high groups, a baseline serum concentration of 50 nmol/L 25(OH)D and baseline dietary protein intake of 1.0 g/kg/d were used as cut offs.

Results: At baseline, participants with lower 25(OH)D concentrations showed lower muscle mass, strength and function compared with participants with a high 25(OH)D, while the group with lower protein intake (g/kg/day) had more muscle mass at baseline compared with the participants with higher protein intake. Participants with higher baseline 25(OH)D concentrations and dietary protein intake had, independent of other determinants, greater gain in appendicular muscle mass, skeletal muscle index (aMM/h(2)), and relative appendicular muscle mass (aMM/body weight × 100%) in response to the nutritional intervention. There was no effect modification of baseline 25(OH)D status or protein intake on change in chair-stand test.

Conclusions: Sufficient baseline levels of 25(OH)D and protein intake may be required to increase muscle mass as a result of intervention with a vitamin D and protein supplement in sarcopenic older adults. This suggests that current cut-offs in the recommendations for vitamin D and protein intake could be considered the "minimum" for adults with sarcopenia to respond adequately to nutrition strategies aimed at attenuating muscle loss.

Original languageEnglish
Pages (from-to)551-557
Number of pages7
JournalEuropean Journal of Clinical Nutrition
Volume37
Issue number2
Early online date17 Jan 2017
DOIs
Publication statusPublished - Apr 2018

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Muscles
Proteins
Dietary Proteins
Vitamin D
Sarcopenia
25-hydroxyvitamin D
Muscle Strength
Nutritional Status
Serum
Leucine
Lower Extremity
Skeletal Muscle
Body Weight
Food

Keywords

  • Oral nutritional supplement;
  • Sarcopenia
  • 25-Hydroxyvitamin D
  • Protein intake
  • Muscle mass

Cite this

Verlaan, Sjors ; Maier, Andrea B. ; Bauer, Jürgen M. ; Bautmans, Ivan ; Brandt, Kirsten ; Donini, Lorenzo M. ; Maggio, Marcello ; McMurdo, Marion E. T. ; Mets, Tony ; Seal, Chris ; Wijers, Sander L. J. ; Sieber, Cornel ; Boirie, Yves ; Cederholm, Tommy. / Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study. In: European Journal of Clinical Nutrition. 2018 ; Vol. 37, No. 2. pp. 551-557.
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abstract = "Background: Inadequate nutritional intake and altered response of aging muscles to anabolic stimuli from nutrients contribute to the development of sarcopenia. Nutritional interventions show inconsistent results in sarcopenic older adults, which might be influenced by their basal nutritional status.Objective: To test if baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations and dietary protein intake influenced changes in muscle mass and function in older adults who received nutritional intervention.Methods and Design: Post-hoc analysis was performed in the PROVIDE study that was a randomized controlled, double blind trial among 380 sarcopenic older adults. This study showed that those who received a vitamin D and leucine-enriched whey protein medical nutrition drink for 13 weeks gained more appendicular muscle mass (aMM), and improved lower-extremity function as assessed by the chair stand test compared with controls. To define low and high groups, a baseline serum concentration of 50 nmol/L 25(OH)D and baseline dietary protein intake of 1.0 g/kg/d were used as cut offs.Results: At baseline, participants with lower 25(OH)D concentrations showed lower muscle mass, strength and function compared with participants with a high 25(OH)D, while the group with lower protein intake (g/kg/day) had more muscle mass at baseline compared with the participants with higher protein intake. Participants with higher baseline 25(OH)D concentrations and dietary protein intake had, independent of other determinants, greater gain in appendicular muscle mass, skeletal muscle index (aMM/h(2)), and relative appendicular muscle mass (aMM/body weight × 100{\%}) in response to the nutritional intervention. There was no effect modification of baseline 25(OH)D status or protein intake on change in chair-stand test.Conclusions: Sufficient baseline levels of 25(OH)D and protein intake may be required to increase muscle mass as a result of intervention with a vitamin D and protein supplement in sarcopenic older adults. This suggests that current cut-offs in the recommendations for vitamin D and protein intake could be considered the {"}minimum{"} for adults with sarcopenia to respond adequately to nutrition strategies aimed at attenuating muscle loss.",
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author = "Sjors Verlaan and Maier, {Andrea B.} and Bauer, {J{\"u}rgen M.} and Ivan Bautmans and Kirsten Brandt and Donini, {Lorenzo M.} and Marcello Maggio and McMurdo, {Marion E. T.} and Tony Mets and Chris Seal and Wijers, {Sander L. J.} and Cornel Sieber and Yves Boirie and Tommy Cederholm",
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Verlaan, S, Maier, AB, Bauer, JM, Bautmans, I, Brandt, K, Donini, LM, Maggio, M, McMurdo, MET, Mets, T, Seal, C, Wijers, SLJ, Sieber, C, Boirie, Y & Cederholm, T 2018, 'Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study', European Journal of Clinical Nutrition, vol. 37, no. 2, pp. 551-557. https://doi.org/10.1016/j.clnu.2017.01.005

Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study. / Verlaan, Sjors (Lead / Corresponding author); Maier, Andrea B.; Bauer, Jürgen M.; Bautmans, Ivan; Brandt, Kirsten; Donini, Lorenzo M.; Maggio, Marcello; McMurdo, Marion E. T.; Mets, Tony; Seal, Chris; Wijers, Sander L. J.; Sieber, Cornel; Boirie, Yves; Cederholm, Tommy.

In: European Journal of Clinical Nutrition, Vol. 37, No. 2, 04.2018, p. 551-557.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study

AU - Verlaan, Sjors

AU - Maier, Andrea B.

AU - Bauer, Jürgen M.

AU - Bautmans, Ivan

AU - Brandt, Kirsten

AU - Donini, Lorenzo M.

AU - Maggio, Marcello

AU - McMurdo, Marion E. T.

AU - Mets, Tony

AU - Seal, Chris

AU - Wijers, Sander L. J.

AU - Sieber, Cornel

AU - Boirie, Yves

AU - Cederholm, Tommy

N1 - This study was financially supported and study products were provided by Nutricia Research, Nutricia Advanced Medical Nutrition.

PY - 2018/4

Y1 - 2018/4

N2 - Background: Inadequate nutritional intake and altered response of aging muscles to anabolic stimuli from nutrients contribute to the development of sarcopenia. Nutritional interventions show inconsistent results in sarcopenic older adults, which might be influenced by their basal nutritional status.Objective: To test if baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations and dietary protein intake influenced changes in muscle mass and function in older adults who received nutritional intervention.Methods and Design: Post-hoc analysis was performed in the PROVIDE study that was a randomized controlled, double blind trial among 380 sarcopenic older adults. This study showed that those who received a vitamin D and leucine-enriched whey protein medical nutrition drink for 13 weeks gained more appendicular muscle mass (aMM), and improved lower-extremity function as assessed by the chair stand test compared with controls. To define low and high groups, a baseline serum concentration of 50 nmol/L 25(OH)D and baseline dietary protein intake of 1.0 g/kg/d were used as cut offs.Results: At baseline, participants with lower 25(OH)D concentrations showed lower muscle mass, strength and function compared with participants with a high 25(OH)D, while the group with lower protein intake (g/kg/day) had more muscle mass at baseline compared with the participants with higher protein intake. Participants with higher baseline 25(OH)D concentrations and dietary protein intake had, independent of other determinants, greater gain in appendicular muscle mass, skeletal muscle index (aMM/h(2)), and relative appendicular muscle mass (aMM/body weight × 100%) in response to the nutritional intervention. There was no effect modification of baseline 25(OH)D status or protein intake on change in chair-stand test.Conclusions: Sufficient baseline levels of 25(OH)D and protein intake may be required to increase muscle mass as a result of intervention with a vitamin D and protein supplement in sarcopenic older adults. This suggests that current cut-offs in the recommendations for vitamin D and protein intake could be considered the "minimum" for adults with sarcopenia to respond adequately to nutrition strategies aimed at attenuating muscle loss.

AB - Background: Inadequate nutritional intake and altered response of aging muscles to anabolic stimuli from nutrients contribute to the development of sarcopenia. Nutritional interventions show inconsistent results in sarcopenic older adults, which might be influenced by their basal nutritional status.Objective: To test if baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations and dietary protein intake influenced changes in muscle mass and function in older adults who received nutritional intervention.Methods and Design: Post-hoc analysis was performed in the PROVIDE study that was a randomized controlled, double blind trial among 380 sarcopenic older adults. This study showed that those who received a vitamin D and leucine-enriched whey protein medical nutrition drink for 13 weeks gained more appendicular muscle mass (aMM), and improved lower-extremity function as assessed by the chair stand test compared with controls. To define low and high groups, a baseline serum concentration of 50 nmol/L 25(OH)D and baseline dietary protein intake of 1.0 g/kg/d were used as cut offs.Results: At baseline, participants with lower 25(OH)D concentrations showed lower muscle mass, strength and function compared with participants with a high 25(OH)D, while the group with lower protein intake (g/kg/day) had more muscle mass at baseline compared with the participants with higher protein intake. Participants with higher baseline 25(OH)D concentrations and dietary protein intake had, independent of other determinants, greater gain in appendicular muscle mass, skeletal muscle index (aMM/h(2)), and relative appendicular muscle mass (aMM/body weight × 100%) in response to the nutritional intervention. There was no effect modification of baseline 25(OH)D status or protein intake on change in chair-stand test.Conclusions: Sufficient baseline levels of 25(OH)D and protein intake may be required to increase muscle mass as a result of intervention with a vitamin D and protein supplement in sarcopenic older adults. This suggests that current cut-offs in the recommendations for vitamin D and protein intake could be considered the "minimum" for adults with sarcopenia to respond adequately to nutrition strategies aimed at attenuating muscle loss.

KW - Oral nutritional supplement;

KW - Sarcopenia

KW - 25-Hydroxyvitamin D

KW - Protein intake

KW - Muscle mass

U2 - 10.1016/j.clnu.2017.01.005

DO - 10.1016/j.clnu.2017.01.005

M3 - Article

C2 - 28132725

VL - 37

SP - 551

EP - 557

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - 2

ER -