Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation

Paul Talalay (Lead / Corresponding author), Jed W. Fahey, Zachary R. Healy, Scott L. Wehage, Andrea L. Benedict, Christine Min, Albena T. Dinkova-Kostova

    Research output: Contribution to journalArticle

    141 Citations (Scopus)

    Abstract

    UV radiation (UVR) is a complete carcinogen that elicits a constellation of pathological events, including direct DNA damage, generation of reactive oxidants that peroxidize lipids and damage other cellular components, initiation of inflammation, and suppression of the immune response. Recent dramatic increases in the incidence of nonmelanoma skin cancers are largely attributable to higher exposure of an aging population to UVR. Therefore, the development of cellular strategies for intrinsic protection of the skin against the deleterious effects of UVR is imperative. Here we show that erythema resulting from UVR is a comprehensive and noninvasive biomarker for assessing UVR damage and can be precisely and easily quantified in human skin. Topical application of sulforaphane-rich extracts of 3-day-old broccoli sprouts upregulated phase 2 enzymes in the mouse and human skin, protected against UVR-induced inflammation and edema in mice, and reduced susceptibility to erythema arising from narrow-band 311-nm UVR in humans. In six human subjects (three males and three females, 28-53 years of age), the mean reduction in erythema across six doses of UVR (300-800 mJ/cm2 in 100 mJ/cm2 increments) was 37.7% (range 8.37-78.1%; P = 0.025). This protection against a carcinogen in humans is catalytic and long lasting.

    Original languageEnglish
    Pages (from-to)17500-17505
    Number of pages6
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume104
    Issue number44
    DOIs
    Publication statusPublished - 30 Oct 2007

    Fingerprint

    Radiation
    Skin
    Erythema
    Carcinogens
    Inflammation
    Brassica
    Radiation Effects
    Skin Neoplasms
    sulforafan
    Oxidants
    DNA Damage
    Edema
    Biomarkers
    Lipids
    Incidence
    Enzymes
    Population

    Keywords

    • Chemoprotection
    • Erythema
    • Nicotinamide:quinone oxidoreductase 1
    • Skin tumor

    Cite this

    Talalay, Paul ; Fahey, Jed W. ; Healy, Zachary R. ; Wehage, Scott L. ; Benedict, Andrea L. ; Min, Christine ; Dinkova-Kostova, Albena T. / Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation. In: Proceedings of the National Academy of Sciences of the United States of America. 2007 ; Vol. 104, No. 44. pp. 17500-17505.
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    Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation. / Talalay, Paul (Lead / Corresponding author); Fahey, Jed W.; Healy, Zachary R.; Wehage, Scott L.; Benedict, Andrea L.; Min, Christine; Dinkova-Kostova, Albena T.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 44, 30.10.2007, p. 17500-17505.

    Research output: Contribution to journalArticle

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