Abstract
The small ubiquitin-like modifier (SUMO) is involved in many cellular processes and is required for normal growth and development in all eukaryotes. Whereas lower eukaryotes have a single version of SUMO, higher eukaryotes have three versions: SUMO-1, -2 and -3. Similarly to most other ubiquitin-like proteins, the primary translation products of the SUMO genes need to be proteolytically processed to expose the C-terminal glycine that will be linked to lysine side chains in substrates. Processing of SUMO precursors is mediated by SUMO-specific proteases that also remove SUMO from modified proteins and depolymerise poly-SUMO chains.
Original language | English |
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Pages (from-to) | 370-6 |
Number of pages | 7 |
Journal | Trends in Cell Biology |
Volume | 17 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2007 |
Keywords
- Cysteine Endopeptidases
- Endopeptidases
- Gene Expression Regulation
- Humans
- Models, Molecular
- Phylogeny
- Protein Conformation
- Protein Isoforms
- Protein Processing, Post-Translational
- Saccharomyces cerevisiae Proteins
- Small Ubiquitin-Related Modifier Proteins
- Ubiquitin