SUMO-specific proteases: a twist in the tail

    Research output: Contribution to journalArticle

    216 Citations (Scopus)

    Abstract

    The small ubiquitin-like modifier (SUMO) is involved in many cellular processes and is required for normal growth and development in all eukaryotes. Whereas lower eukaryotes have a single version of SUMO, higher eukaryotes have three versions: SUMO-1, -2 and -3. Similarly to most other ubiquitin-like proteins, the primary translation products of the SUMO genes need to be proteolytically processed to expose the C-terminal glycine that will be linked to lysine side chains in substrates. Processing of SUMO precursors is mediated by SUMO-specific proteases that also remove SUMO from modified proteins and depolymerise poly-SUMO chains.

    Original languageEnglish
    Pages (from-to)370-6
    Number of pages7
    JournalTrends in Cell Biology
    Volume17
    Issue number8
    DOIs
    Publication statusPublished - Aug 2007

    Keywords

    • Cysteine Endopeptidases
    • Endopeptidases
    • Gene Expression Regulation
    • Humans
    • Models, Molecular
    • Phylogeny
    • Protein Conformation
    • Protein Isoforms
    • Protein Processing, Post-Translational
    • Saccharomyces cerevisiae Proteins
    • Small Ubiquitin-Related Modifier Proteins
    • Ubiquitin

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