SUMO-specific proteases: a twist in the tail

TY - JOUR

T1 - SUMO-specific proteases

T2 - a twist in the tail

AU - Hay, Ronald Thomas

PY - 2007/8

Y1 - 2007/8

N2 - The small ubiquitin-like modifier (SUMO) is involved in many cellular processes and is required for normal growth and development in all eukaryotes. Whereas lower eukaryotes have a single version of SUMO, higher eukaryotes have three versions: SUMO-1, -2 and -3. Similarly to most other ubiquitin-like proteins, the primary translation products of the SUMO genes need to be proteolytically processed to expose the C-terminal glycine that will be linked to lysine side chains in substrates. Processing of SUMO precursors is mediated by SUMO-specific proteases that also remove SUMO from modified proteins and depolymerise poly-SUMO chains.

AB - The small ubiquitin-like modifier (SUMO) is involved in many cellular processes and is required for normal growth and development in all eukaryotes. Whereas lower eukaryotes have a single version of SUMO, higher eukaryotes have three versions: SUMO-1, -2 and -3. Similarly to most other ubiquitin-like proteins, the primary translation products of the SUMO genes need to be proteolytically processed to expose the C-terminal glycine that will be linked to lysine side chains in substrates. Processing of SUMO precursors is mediated by SUMO-specific proteases that also remove SUMO from modified proteins and depolymerise poly-SUMO chains.

KW - Cysteine Endopeptidases

KW - Endopeptidases

KW - Gene Expression Regulation

KW - Humans

KW - Models, Molecular

KW - Phylogeny

KW - Protein Conformation

KW - Protein Isoforms

KW - Protein Processing, Post-Translational

KW - Saccharomyces cerevisiae Proteins

KW - Small Ubiquitin-Related Modifier Proteins

KW - Ubiquitin

U2 - 10.1016/j.tcb.2007.08.002

DO - 10.1016/j.tcb.2007.08.002

M3 - Article

C2 - 17768054

SN - 0962-8924

VL - 17

SP - 370

EP - 376

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 8

ER -