18F-barbiturates are PET tracers with diagnostic potential in Alzheimer’s disease

Elisa Calamai; Sergio Dall’angelo; David Koss; Juozas Domarkas; Timothy J. McCarthy; Marco Mingarelli; Gernot Riedel; Lutz F. Schweiger; Andy Welch; Bettina Platt; Matteo Zanda

doi:10.1039/c2cc38443d

¹⁸F-barbiturates are PET tracers with diagnostic potential in Alzheimer’s disease

Elisa Calamai, Sergio Dall’angelo, David Koss, Juozas Domarkas, Timothy J. McCarthy, Marco Mingarelli, Gernot Riedel, Lutz F. Schweiger, Andy Welch, Bettina Platt (Lead / Corresponding author), Matteo Zanda (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [¹⁸F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [¹⁸F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.

Original language	English
Pages (from-to)	792-794
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	8
Early online date	4 Dec 2012
DOIs	https://doi.org/10.1039/c2cc38443d
Publication status	Published - 2013

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "18F-barbiturates are PET tracers with diagnostic potential in Alzheimer{\textquoteright}s disease",

abstract = "Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [18F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [18F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.",

author = "Elisa Calamai and Sergio Dall{\textquoteright}angelo and David Koss and Juozas Domarkas and McCarthy, {Timothy J.} and Marco Mingarelli and Gernot Riedel and Schweiger, {Lutz F.} and Andy Welch and Bettina Platt and Matteo Zanda",

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doi = "10.1039/c2cc38443d",

language = "English",

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publisher = "Royal Society of Chemistry",

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T1 - 18F-barbiturates are PET tracers with diagnostic potential in Alzheimer’s disease

AU - Calamai, Elisa

AU - Dall’angelo, Sergio

AU - Koss, David

AU - Domarkas, Juozas

AU - McCarthy, Timothy J.

AU - Mingarelli, Marco

AU - Riedel, Gernot

AU - Schweiger, Lutz F.

AU - Welch, Andy

AU - Platt, Bettina

AU - Zanda, Matteo

PY - 2013

Y1 - 2013

N2 - Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [18F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [18F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.

AB - Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [18F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [18F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.

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SN - 1359-7345

VL - 49

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EP - 794

JO - Chemical Communications

JF - Chemical Communications

IS - 8

ER -

¹⁸F-barbiturates are PET tracers with diagnostic potential in Alzheimer’s disease

Abstract

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