Supplementation of infant formula with long-chain polyunsaturated fatty acids does not influence the growth of term infants

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Abstract

Background: Adequate growth is an important indicator of health and well-being in infants. 

Objective: Our objective was to determine the effect of supplementing infant formula with long-chain polyunsaturated fatty acids (LCPUFAs) on the growth of term infants. 

Design: Using the methodology outlined by the Cochrane Collaboration, we reviewed all known randomized controlled trials that involved LCPUFA supplementation of infant formula fed to term infants. Outcome measures were weight, length, and head circumference. Original data obtained from the investigators of published trials were used. Outcomes were analyzed with fixed-effects or random-effects model meta-analyses and were reported as weighted mean differences with 95% CIs. 

Results: We identified 14 eligible trials that had data available for meta-analysis (1846 infants). Trial quality was generally high. Meta-analysis showed no significant effect of LCPUFA supplementation on infant weight, length, or head circumference at any assessment age. Similarly, subgroup analyses showed that supplementation with only n-3 LCPUFAs (no arachidonic acid) had no significant effect on infant weight, length, or head circumference. The source of LCPUFA supplementation (phospholipid or triacylglycerol) also did not significantly affect infant growth. 

Conclusion: We found no evidence that LCPUFA supplementation of infant formula influences the growth of term infants in either a positive or a negative way.

Original languageEnglish
Pages (from-to)1094-1101
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume81
Issue number5
DOIs
Publication statusPublished - 1 Jan 2005

Fingerprint

Infant Formula
Unsaturated Fatty Acids
Growth
Meta-Analysis
Head
Weights and Measures
Infant Welfare
Arachidonic Acid
Phospholipids
Triglycerides
Randomized Controlled Trials
Research Personnel
Outcome Assessment (Health Care)
Health

Keywords

  • AA
  • Arachidonic acid
  • DHA
  • Docosahexaenoic acid
  • Growth
  • Infant
  • Meta-analysis
  • Systematic review

Cite this

@article{66425c39e16f4ab7ba4a329b56e9027c,
title = "Supplementation of infant formula with long-chain polyunsaturated fatty acids does not influence the growth of term infants",
abstract = "Background: Adequate growth is an important indicator of health and well-being in infants. Objective: Our objective was to determine the effect of supplementing infant formula with long-chain polyunsaturated fatty acids (LCPUFAs) on the growth of term infants. Design: Using the methodology outlined by the Cochrane Collaboration, we reviewed all known randomized controlled trials that involved LCPUFA supplementation of infant formula fed to term infants. Outcome measures were weight, length, and head circumference. Original data obtained from the investigators of published trials were used. Outcomes were analyzed with fixed-effects or random-effects model meta-analyses and were reported as weighted mean differences with 95{\%} CIs. Results: We identified 14 eligible trials that had data available for meta-analysis (1846 infants). Trial quality was generally high. Meta-analysis showed no significant effect of LCPUFA supplementation on infant weight, length, or head circumference at any assessment age. Similarly, subgroup analyses showed that supplementation with only n-3 LCPUFAs (no arachidonic acid) had no significant effect on infant weight, length, or head circumference. The source of LCPUFA supplementation (phospholipid or triacylglycerol) also did not significantly affect infant growth. Conclusion: We found no evidence that LCPUFA supplementation of infant formula influences the growth of term infants in either a positive or a negative way.",
keywords = "AA, Arachidonic acid, DHA, Docosahexaenoic acid, Growth, Infant, Meta-analysis, Systematic review",
author = "Maria Makrides and Gibson, {Robert A.} and Tuesday Udell and Karin Ried and Carlo Agostoni and Nancy Auestad and Eileen Birch and Carlson, {Susan E.} and Tamas Decsi and Deborah Diersen-Schade and William Goldman and Forsyth, {James S.} and Robert Hall and Harris, {Cheryl L.} and Dennis Hoffman and Innis, {Sheila M.} and Berthold Koletzko and Alexandre Lapillonne and Merkel, {Kimberly L.} and Michael Montalto and James Moorcraft and Geraint Morris and Ricardo Uauy and Wells, {John C.K.} and Peter Willatts",
year = "2005",
month = "1",
day = "1",
doi = "10.1093/ajcn/81.5.1094",
language = "English",
volume = "81",
pages = "1094--1101",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
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TY - JOUR

T1 - Supplementation of infant formula with long-chain polyunsaturated fatty acids does not influence the growth of term infants

AU - Makrides, Maria

AU - Gibson, Robert A.

AU - Udell, Tuesday

AU - Ried, Karin

AU - Agostoni, Carlo

AU - Auestad, Nancy

AU - Birch, Eileen

AU - Carlson, Susan E.

AU - Decsi, Tamas

AU - Diersen-Schade, Deborah

AU - Goldman, William

AU - Forsyth, James S.

AU - Hall, Robert

AU - Harris, Cheryl L.

AU - Hoffman, Dennis

AU - Innis, Sheila M.

AU - Koletzko, Berthold

AU - Lapillonne, Alexandre

AU - Merkel, Kimberly L.

AU - Montalto, Michael

AU - Moorcraft, James

AU - Morris, Geraint

AU - Uauy, Ricardo

AU - Wells, John C.K.

AU - Willatts, Peter

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Background: Adequate growth is an important indicator of health and well-being in infants. Objective: Our objective was to determine the effect of supplementing infant formula with long-chain polyunsaturated fatty acids (LCPUFAs) on the growth of term infants. Design: Using the methodology outlined by the Cochrane Collaboration, we reviewed all known randomized controlled trials that involved LCPUFA supplementation of infant formula fed to term infants. Outcome measures were weight, length, and head circumference. Original data obtained from the investigators of published trials were used. Outcomes were analyzed with fixed-effects or random-effects model meta-analyses and were reported as weighted mean differences with 95% CIs. Results: We identified 14 eligible trials that had data available for meta-analysis (1846 infants). Trial quality was generally high. Meta-analysis showed no significant effect of LCPUFA supplementation on infant weight, length, or head circumference at any assessment age. Similarly, subgroup analyses showed that supplementation with only n-3 LCPUFAs (no arachidonic acid) had no significant effect on infant weight, length, or head circumference. The source of LCPUFA supplementation (phospholipid or triacylglycerol) also did not significantly affect infant growth. Conclusion: We found no evidence that LCPUFA supplementation of infant formula influences the growth of term infants in either a positive or a negative way.

AB - Background: Adequate growth is an important indicator of health and well-being in infants. Objective: Our objective was to determine the effect of supplementing infant formula with long-chain polyunsaturated fatty acids (LCPUFAs) on the growth of term infants. Design: Using the methodology outlined by the Cochrane Collaboration, we reviewed all known randomized controlled trials that involved LCPUFA supplementation of infant formula fed to term infants. Outcome measures were weight, length, and head circumference. Original data obtained from the investigators of published trials were used. Outcomes were analyzed with fixed-effects or random-effects model meta-analyses and were reported as weighted mean differences with 95% CIs. Results: We identified 14 eligible trials that had data available for meta-analysis (1846 infants). Trial quality was generally high. Meta-analysis showed no significant effect of LCPUFA supplementation on infant weight, length, or head circumference at any assessment age. Similarly, subgroup analyses showed that supplementation with only n-3 LCPUFAs (no arachidonic acid) had no significant effect on infant weight, length, or head circumference. The source of LCPUFA supplementation (phospholipid or triacylglycerol) also did not significantly affect infant growth. Conclusion: We found no evidence that LCPUFA supplementation of infant formula influences the growth of term infants in either a positive or a negative way.

KW - AA

KW - Arachidonic acid

KW - DHA

KW - Docosahexaenoic acid

KW - Growth

KW - Infant

KW - Meta-analysis

KW - Systematic review

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U2 - 10.1093/ajcn/81.5.1094

DO - 10.1093/ajcn/81.5.1094

M3 - Article

VL - 81

SP - 1094

EP - 1101

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -