Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis

Alanna de Korompay; Jenny C. Hill; James F. Carter; Niamh NicDaeid; Richard Sleeman

doi:10.1016/j.chroma.2007.11.054

Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis

Alanna de Korompay, Jenny C. Hill, James F. Carter (Lead / Corresponding author), Niamh NicDaeid, Richard Sleeman

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

A method was developed for the isolation of 3,4-methylenedioxymethylamphetamine (MDMA) and other active ingredients from illicit ecstasy tablets. The method employed supported liquid extraction (SLE) with cartridges containing a modified form of diatomaceous earth. The method developed was simple and robust and the extract could be analysed directly, by GC-MS, to identify ingredients and reduced in volume for isotope ratio MS analysis of both d C and d N. The technique was shown to be highly reproducible, independent of the tablet matrix and considerably faster than existing liquid-liquid extraction methods. Crucially, no significant isotopic fractionation was observed as a result of the extraction process.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Journal of Chromatography. A
Volume	1178
Issue number	1-2
DOIs	https://doi.org/10.1016/j.chroma.2007.11.054
Publication status	Published - 18 Jan 2008

Keywords

3,4-Methylenedioxymethylamphetamine (MDMA)
Ecstasy tablets
Supported liquid–liquid extraction (SLE)
Isotopic analysis
Isotope ratio mass spectrometry (IRMS)

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10.1016/j.chroma.2007.11.054

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title = "Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis",

abstract = "A method was developed for the isolation of 3,4-methylenedioxymethylamphetamine (MDMA) and other active ingredients from illicit ecstasy tablets. The method employed supported liquid extraction (SLE) with cartridges containing a modified form of diatomaceous earth. The method developed was simple and robust and the extract could be analysed directly, by GC-MS, to identify ingredients and reduced in volume for isotope ratio MS analysis of both d C and d N. The technique was shown to be highly reproducible, independent of the tablet matrix and considerably faster than existing liquid-liquid extraction methods. Crucially, no significant isotopic fractionation was observed as a result of the extraction process.",

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Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis. / de Korompay, Alanna; Hill, Jenny C.; Carter, James F. (Lead / Corresponding author) et al.
In: Journal of Chromatography. A, Vol. 1178, No. 1-2, 18.01.2008, p. 1-8.

Research output: Contribution to journal › Article › peer-review

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T1 - Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis

AU - de Korompay, Alanna

AU - Hill, Jenny C.

AU - Carter, James F.

AU - NicDaeid, Niamh

AU - Sleeman, Richard

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AB - A method was developed for the isolation of 3,4-methylenedioxymethylamphetamine (MDMA) and other active ingredients from illicit ecstasy tablets. The method employed supported liquid extraction (SLE) with cartridges containing a modified form of diatomaceous earth. The method developed was simple and robust and the extract could be analysed directly, by GC-MS, to identify ingredients and reduced in volume for isotope ratio MS analysis of both d C and d N. The technique was shown to be highly reproducible, independent of the tablet matrix and considerably faster than existing liquid-liquid extraction methods. Crucially, no significant isotopic fractionation was observed as a result of the extraction process.

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KW - Supported liquid–liquid extraction (SLE)

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Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis

Abstract

Keywords

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