A method was developed for the isolation of 3,4-methylenedioxymethylamphetamine (MDMA) and other active ingredients from illicit ecstasy tablets. The method employed supported liquid extraction (SLE) with cartridges containing a modified form of diatomaceous earth. The method developed was simple and robust and the extract could be analysed directly, by GC-MS, to identify ingredients and reduced in volume for isotope ratio MS analysis of both d C and d N. The technique was shown to be highly reproducible, independent of the tablet matrix and considerably faster than existing liquid-liquid extraction methods. Crucially, no significant isotopic fractionation was observed as a result of the extraction process.
- 3,4-Methylenedioxymethylamphetamine (MDMA)
- Ecstasy tablets
- Supported liquid–liquid extraction (SLE)
- Isotopic analysis
- Isotope ratio mass spectrometry (IRMS)
de Korompay, A., Hill, J. C., Carter, J. F., NicDaeid, N., & Sleeman, R. (2008). Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis. Journal of Chromatography. A, 1178(1-2), 1-8. https://doi.org/10.1016/j.chroma.2007.11.054