Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis

TY - JOUR

T1 - Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis

AU - de Korompay, Alanna

AU - Hill, Jenny C.

AU - Carter, James F.

AU - NicDaeid, Niamh

AU - Sleeman, Richard

PY - 2008/1/18

Y1 - 2008/1/18

N2 - A method was developed for the isolation of 3,4-methylenedioxymethylamphetamine (MDMA) and other active ingredients from illicit ecstasy tablets. The method employed supported liquid extraction (SLE) with cartridges containing a modified form of diatomaceous earth. The method developed was simple and robust and the extract could be analysed directly, by GC-MS, to identify ingredients and reduced in volume for isotope ratio MS analysis of both d C and d N. The technique was shown to be highly reproducible, independent of the tablet matrix and considerably faster than existing liquid-liquid extraction methods. Crucially, no significant isotopic fractionation was observed as a result of the extraction process.

AB - A method was developed for the isolation of 3,4-methylenedioxymethylamphetamine (MDMA) and other active ingredients from illicit ecstasy tablets. The method employed supported liquid extraction (SLE) with cartridges containing a modified form of diatomaceous earth. The method developed was simple and robust and the extract could be analysed directly, by GC-MS, to identify ingredients and reduced in volume for isotope ratio MS analysis of both d C and d N. The technique was shown to be highly reproducible, independent of the tablet matrix and considerably faster than existing liquid-liquid extraction methods. Crucially, no significant isotopic fractionation was observed as a result of the extraction process.

KW - 3,4-Methylenedioxymethylamphetamine (MDMA)

KW - Ecstasy tablets

KW - Supported liquid–liquid extraction (SLE)

KW - Isotopic analysis

KW - Isotope ratio mass spectrometry (IRMS)

UR - https://www.scopus.com/pages/publications/37549004774

U2 - 10.1016/j.chroma.2007.11.054

DO - 10.1016/j.chroma.2007.11.054

M3 - Article

C2 - 18070626

AN - SCOPUS:37549004774

SN - 0021-9673

VL - 1178

SP - 1

EP - 8

JO - Journal of Chromatography. A

JF - Journal of Chromatography. A

IS - 1-2

ER -