SURA2 targeting for cardioprotection?

Aleksandar Jovanovic, Sofija Jovanovic

    Research output: Contribution to journalReview article

    15 Citations (Scopus)

    Abstract

    SUR2A is an ATP-binding protein known to serve as a regulatory subunit of metabolic-sensing, cardio protective sarcolemmal ATIP-sensitive K+ (K-ATP) channels. It has been recently found that a moderate increase in expression of SUR2A protects the heart against different types of metabolic stresses, including ischaemia/reperfusion and hypoxia. Although the sarcolemmal K-ATP channel is a multiprotein complex composed of many proteins in vivo, it seems that an increase in SUR2A levels is sufficient to increase the number of sarcolemmal K-ATP channels. This effect of SUR2A could be due to SUR2A being the rate-limiting factor in generating fully composed sarcolemmal K-ATP channels. An increased number of sarcolemmal K-ATP channels seems to protect the heart by regulating action membrane potential, inhibiting Ca2+ influx and preventing Ca2+ overload, although an additional yet to be recognised mechanism independent of K-ATP channels activity cannot be excluded.

    Original languageEnglish
    Pages (from-to)189-193
    Number of pages5
    JournalCurrent Opinion in Pharmacology
    Volume9
    Issue number2
    DOIs
    Publication statusPublished - Apr 2009

    Keywords

    • SENSITIVE POTASSIUM CHANNELS
    • SARCOLEMMAL K-ATP
    • GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
    • ISCHEMIA/REPERFUSION INJURY
    • CREATINE-KINASE
    • H9C2 CELLS
    • ISCHEMIA
    • HEART
    • SUBUNITS
    • PROTEIN

    Cite this

    Jovanovic, Aleksandar ; Jovanovic, Sofija. / SURA2 targeting for cardioprotection?. In: Current Opinion in Pharmacology. 2009 ; Vol. 9, No. 2. pp. 189-193.
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    title = "SURA2 targeting for cardioprotection?",
    abstract = "SUR2A is an ATP-binding protein known to serve as a regulatory subunit of metabolic-sensing, cardio protective sarcolemmal ATIP-sensitive K+ (K-ATP) channels. It has been recently found that a moderate increase in expression of SUR2A protects the heart against different types of metabolic stresses, including ischaemia/reperfusion and hypoxia. Although the sarcolemmal K-ATP channel is a multiprotein complex composed of many proteins in vivo, it seems that an increase in SUR2A levels is sufficient to increase the number of sarcolemmal K-ATP channels. This effect of SUR2A could be due to SUR2A being the rate-limiting factor in generating fully composed sarcolemmal K-ATP channels. An increased number of sarcolemmal K-ATP channels seems to protect the heart by regulating action membrane potential, inhibiting Ca2+ influx and preventing Ca2+ overload, although an additional yet to be recognised mechanism independent of K-ATP channels activity cannot be excluded.",
    keywords = "SENSITIVE POTASSIUM CHANNELS, SARCOLEMMAL K-ATP, GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, ISCHEMIA/REPERFUSION INJURY, CREATINE-KINASE, H9C2 CELLS, ISCHEMIA, HEART, SUBUNITS, PROTEIN",
    author = "Aleksandar Jovanovic and Sofija Jovanovic",
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    language = "English",
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    SURA2 targeting for cardioprotection? / Jovanovic, Aleksandar; Jovanovic, Sofija.

    In: Current Opinion in Pharmacology, Vol. 9, No. 2, 04.2009, p. 189-193.

    Research output: Contribution to journalReview article

    TY - JOUR

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    AU - Jovanovic, Aleksandar

    AU - Jovanovic, Sofija

    PY - 2009/4

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    N2 - SUR2A is an ATP-binding protein known to serve as a regulatory subunit of metabolic-sensing, cardio protective sarcolemmal ATIP-sensitive K+ (K-ATP) channels. It has been recently found that a moderate increase in expression of SUR2A protects the heart against different types of metabolic stresses, including ischaemia/reperfusion and hypoxia. Although the sarcolemmal K-ATP channel is a multiprotein complex composed of many proteins in vivo, it seems that an increase in SUR2A levels is sufficient to increase the number of sarcolemmal K-ATP channels. This effect of SUR2A could be due to SUR2A being the rate-limiting factor in generating fully composed sarcolemmal K-ATP channels. An increased number of sarcolemmal K-ATP channels seems to protect the heart by regulating action membrane potential, inhibiting Ca2+ influx and preventing Ca2+ overload, although an additional yet to be recognised mechanism independent of K-ATP channels activity cannot be excluded.

    AB - SUR2A is an ATP-binding protein known to serve as a regulatory subunit of metabolic-sensing, cardio protective sarcolemmal ATIP-sensitive K+ (K-ATP) channels. It has been recently found that a moderate increase in expression of SUR2A protects the heart against different types of metabolic stresses, including ischaemia/reperfusion and hypoxia. Although the sarcolemmal K-ATP channel is a multiprotein complex composed of many proteins in vivo, it seems that an increase in SUR2A levels is sufficient to increase the number of sarcolemmal K-ATP channels. This effect of SUR2A could be due to SUR2A being the rate-limiting factor in generating fully composed sarcolemmal K-ATP channels. An increased number of sarcolemmal K-ATP channels seems to protect the heart by regulating action membrane potential, inhibiting Ca2+ influx and preventing Ca2+ overload, although an additional yet to be recognised mechanism independent of K-ATP channels activity cannot be excluded.

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    KW - SARCOLEMMAL K-ATP

    KW - GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE

    KW - ISCHEMIA/REPERFUSION INJURY

    KW - CREATINE-KINASE

    KW - H9C2 CELLS

    KW - ISCHEMIA

    KW - HEART

    KW - SUBUNITS

    KW - PROTEIN

    U2 - 10.1016/j.coph.2008.11.003

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