Sural nerve biopsies in Guillain-Barre syndrome: axonal degeneration and macrophage-associated demyelination and absence of cytomegalovirus genome

Richard Hughes, Penny Atkinson, Susan Hall, Philip Coates, Sidney Leibowitz

    Research output: Contribution to journalArticle

    56 Citations (Scopus)

    Abstract

    T-cell infiltration was detected by immunohistochemistry in only 2 of 10 sural nerve biopsies from patients with Guillain-Barré syndrome (GBS). The number of endoneurial macrophages, identified by the monoclonal antibody MAC 387, was increased, compared with the number in 10 cases of axonal neuropathy. Macrophage-associated demyelination was identified in 7 and axonal degeneration in 8 cases. Cytomegalovirus (CMV) genome was not detected with the polymerase chain reaction.
    Original languageEnglish
    Pages (from-to)568-575
    Number of pages8
    JournalMuscle & Nerve
    Volume15
    Issue number5
    DOIs
    Publication statusPublished - 1992

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