Sural nerve biopsies in Guillain-Barre syndrome: axonal degeneration and macrophage-associated demyelination and absence of cytomegalovirus genome

Richard Hughes, Penny Atkinson, Susan Hall, Philip Coates, Sidney Leibowitz

    Research output: Contribution to journalArticle

    54 Citations (Scopus)

    Abstract

    T-cell infiltration was detected by immunohistochemistry in only 2 of 10 sural nerve biopsies from patients with Guillain-Barré syndrome (GBS). The number of endoneurial macrophages, identified by the monoclonal antibody MAC 387, was increased, compared with the number in 10 cases of axonal neuropathy. Macrophage-associated demyelination was identified in 7 and axonal degeneration in 8 cases. Cytomegalovirus (CMV) genome was not detected with the polymerase chain reaction.
    Original languageEnglish
    Pages (from-to)568-575
    Number of pages8
    JournalMuscle & Nerve
    Volume15
    Issue number5
    DOIs
    Publication statusPublished - 1992

    Fingerprint

    Sural Nerve
    Guillain-Barre Syndrome
    Demyelinating Diseases
    Cytomegalovirus
    Macrophages
    Genome
    Biopsy
    Immunohistochemistry
    Monoclonal Antibodies
    T-Lymphocytes
    Polymerase Chain Reaction

    Cite this

    Hughes, Richard ; Atkinson, Penny ; Hall, Susan ; Coates, Philip ; Leibowitz, Sidney. / Sural nerve biopsies in Guillain-Barre syndrome : axonal degeneration and macrophage-associated demyelination and absence of cytomegalovirus genome. In: Muscle & Nerve. 1992 ; Vol. 15, No. 5. pp. 568-575.
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    abstract = "T-cell infiltration was detected by immunohistochemistry in only 2 of 10 sural nerve biopsies from patients with Guillain-Barr{\'e} syndrome (GBS). The number of endoneurial macrophages, identified by the monoclonal antibody MAC 387, was increased, compared with the number in 10 cases of axonal neuropathy. Macrophage-associated demyelination was identified in 7 and axonal degeneration in 8 cases. Cytomegalovirus (CMV) genome was not detected with the polymerase chain reaction.",
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    Sural nerve biopsies in Guillain-Barre syndrome : axonal degeneration and macrophage-associated demyelination and absence of cytomegalovirus genome. / Hughes, Richard; Atkinson, Penny; Hall, Susan; Coates, Philip; Leibowitz, Sidney.

    In: Muscle & Nerve, Vol. 15, No. 5, 1992, p. 568-575.

    Research output: Contribution to journalArticle

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