Sural nerve biopsies in Guillain-Barre syndrome: axonal degeneration and macrophage-associated demyelination and absence of cytomegalovirus genome

TY - JOUR

T1 - Sural nerve biopsies in Guillain-Barre syndrome

T2 - axonal degeneration and macrophage-associated demyelination and absence of cytomegalovirus genome

AU - Hughes, Richard

AU - Atkinson, Penny

AU - Hall, Susan

AU - Coates, Philip

AU - Leibowitz, Sidney

PY - 1992

Y1 - 1992

N2 - T-cell infiltration was detected by immunohistochemistry in only 2 of 10 sural nerve biopsies from patients with Guillain-Barré syndrome (GBS). The number of endoneurial macrophages, identified by the monoclonal antibody MAC 387, was increased, compared with the number in 10 cases of axonal neuropathy. Macrophage-associated demyelination was identified in 7 and axonal degeneration in 8 cases. Cytomegalovirus (CMV) genome was not detected with the polymerase chain reaction.

AB - T-cell infiltration was detected by immunohistochemistry in only 2 of 10 sural nerve biopsies from patients with Guillain-Barré syndrome (GBS). The number of endoneurial macrophages, identified by the monoclonal antibody MAC 387, was increased, compared with the number in 10 cases of axonal neuropathy. Macrophage-associated demyelination was identified in 7 and axonal degeneration in 8 cases. Cytomegalovirus (CMV) genome was not detected with the polymerase chain reaction.

U2 - 10.1002/mus.880150506

DO - 10.1002/mus.880150506

M3 - Article

C2 - 1316554

SN - 0148-639X

VL - 15

SP - 568

EP - 575

JO - Muscle & Nerve

JF - Muscle & Nerve

IS - 5

ER -