Surface sialic acids taken from the host allow trypanosome survival in Tsetse fly vectors

Kisaburo Nagamune, Alvaro Acosta-Serrano, Haruki Uemura, Reto Brun, Christina Kunz-Renggli, Yusuke Maeda, Michael A. J. Ferguson, Taroh Kinoshita

    Research output: Contribution to journalArticlepeer-review

    66 Citations (Scopus)

    Abstract

    The African trypanosome Trypanosoma brucei, which causes sleeping sickness in humans and Nagana disease in livestock, is spread via blood-sucking Tsetse flies. In the fly's intestine, the trypanosomes survive digestive and trypanocidal environments, proliferate, and translocate into the salivary gland, where they become infectious to the next mammalian host. Here, we show that for successful survival in Tsetse flies, the trypanosomes use trans-sialidase to transfer sialic acids that they cannot synthesize from host's glycoconjugates to the glycosylphosphatidylinositols (GPIs), which are abundantly expressed on their surface. Trypanosomes lacking sialic acids due to a defective generation of GPI-anchored trans-sialidase could not survive in the intestine, but regained the ability to survive when sialylated by means of soluble trans-sialidase. Thus, surface sialic acids appear to protect the parasites from the digestive and trypanocidal environments in the midgut of Tsetse flies.

    Original languageEnglish
    Pages (from-to)1445-1450
    Number of pages6
    JournalJournal of Experimental Medicine
    Volume199
    Issue number10
    DOIs
    Publication statusPublished - 17 May 2004

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