Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes, but not with insulin resistance

Paul J. Meakin, Sudhir Chowdhry, Ritu S. Sharma, Fiona B. Ashford, Shaun V. Walsh, Rory J. McCrimmon, Albena T. Dinkova-Kostova, John F. Dillon, John D Hayes (Lead / Corresponding author), Michael L. J. Ashford (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

315 Downloads (Pure)

4 Finished

4 results

Finished

Targeting the Aspartic Protease BACE1 for Inhibition in Order to Increase Hypothalamic Leptin Sensitivity and Reverse Obesity
Ashford, M.
Medical Research Council
1/01/13 → 31/12/15
Project: Research
Pivotal Role of the Keap1-Nrf2 Pathway in the Pathogenesis and Prevention of Non Alcoholic Steatohepatitis Induced Cirrhosis
Ashford, M., Dillon, J., Hayes, J. & McCrimmon, R.
Medical Research Council
1/11/12 → 31/03/16
Project: Research
Application of Selected-Reaction Monitoring (SRM) Mass Spectrometry for the Global Analysis of the Phosphorylation Status of Protein Kinases
Ashford, M., Dillon, J., Hayes, J., McCrimmon, R. & Trost, M.
Medical Research Council
1/11/12 → 31/03/16
Project: Research
Aref#d: 21172. Increased Insulin Sensitivity and Obesity Resistance in Mice Lacking BACE1
Ashford, M.
Wellcome Trust
1/10/09 → 30/09/12
Project: Research