Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse

Patrick S. Costello, Maighread Gallagher, Doreen A. Cantrell

    Research output: Contribution to journalArticle

    172 Citations (Scopus)

    Abstract

    T cell activation is triggered by several hours of contact with peptide-major histocompatibility (MHC) complexes on the surface of antigen-presenting cells (APCs). The nature and location of the sustained signal transduction pathways required for T cell activation are unknown. We show here that the production of phosphatidylinositol(3,4,5)triphosphate (PIP3) was dynamically sustained for hours as T cells responded to antigen. In addition, sustained elevation of PIP3 was essential for T cell proliferation. There was PIP3 accumulation in the T cell-APC contact zone and at the antipodal pole of the cell. The immune synapse is thus not the sole site of sustained signal transduction in activated T cells.
    Original languageEnglish
    Pages (from-to)1082-1089
    Number of pages8
    JournalNature Immunology
    Volume3
    Issue number11
    DOIs
    Publication statusPublished - Nov 2002

    Keywords

    • 1-Phosphatidylinositol 3-Kinase physiology
    • Antigen presentation physiology
    • Lymphocyte activation physiology
    • Membrane lipids metabolism
    • Phosphatidylinositol phosphates metabolism
    • Protein-serine-threonine kinases
    • Signal transduction physiology
    • T lymphocyte subsets immunology

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