Sympathetically mediated vasoconstriction is augmented by angiotensin II in man

D. J. Webb, P. H. Seidelin, N. Benjamin, J. G. Collier, A. D. Struthers

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    In order to determine whether angiotensin II may influence sympathetically mediated arteriolar constriction in man, we have examined the effect of angiotensin II, infused directly into the left brachial artery of normal subjects, on the reduction in forearm blood flow produced by a lower-body negative pressure (LBNP) of 15 mmHg. Angiotensin II (320 fmol/min) caused no reduction in blood flow when given alone but significantly augmented the reduction in blood flow in response to LBNP. The same dose of angiotensin II did not affect a similar reduction in forearm blood flow produced by infused noradrenaline (12.5-50 ng/min). We conclude that angiotensin II augments sympathetically mediated constriction of resistance vessels in man at concentrations with no direct effect on vessel tone. The lack of an effect of angiotensin II on constriction in response to infused noradrenaline suggests the involvement of a presynaptic mechanism.
    Original languageEnglish
    Pages (from-to)S542-S543
    JournalJournal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
    Volume6
    Issue number4
    Publication statusPublished - 1988

    Fingerprint Dive into the research topics of 'Sympathetically mediated vasoconstriction is augmented by angiotensin II in man'. Together they form a unique fingerprint.

    Cite this