Symptomatic and physiological responses to hypoglycaemia induced by human soluble insulin and the analogue Lispro human insulin

R. J. McCrimmon (Lead / Corresponding author), B. M. Frier

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    22 Citations (Scopus)

    Abstract

    The aim of this study was to compare the glycaemic threshold for onset of the clinically detectable sympatho-adrenal (autonomic) reaction (defined as 'R') to hypoglycaemia induced by Lispro human insulin, with that induced by human soluble insulin (HS). The hypoglycaemia symptom profile, counterregulatory hormonal responses, and cognitive performance at R were also compared. Sixteen patients with IDDM, aged 32.5 (20-45) (median (range)) years and duration of IDDM 3.0 (0.5-4.5) years participated in a randomized, double-blind study during which intravenous infusions of either Lispro or HS insulin (2.0 mU kg(-1) min(-1)) were used on separate occasions to lower the blood glucose to the level at which R was induced. For both HS and Lispro, significant increments in systolic blood pressure (p
    Original languageEnglish
    Pages (from-to)929-936
    Number of pages8
    JournalDiabetic Medicine
    Volume14
    Issue number11
    DOIs
    Publication statusPublished - Nov 1997

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