Symptomatic and physiological responses to hypoglycaemia induced by human soluble insulin and the analogue Lispro human insulin

R. J. McCrimmon; B. M. Frier

doi:10.1002/(SICI)1096-9136(199711)14:11<929::AID-DIA477>3.0.CO;2-4

Symptomatic and physiological responses to hypoglycaemia induced by human soluble insulin and the analogue Lispro human insulin

R. J. McCrimmon (Lead / Corresponding author)
, B. M. Frier

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The aim of this study was to compare the glycaemic threshold for onset of the clinically detectable sympatho-adrenal (autonomic) reaction (defined as 'R') to hypoglycaemia induced by Lispro human insulin, with that induced by human soluble insulin (HS). The hypoglycaemia symptom profile, counterregulatory hormonal responses, and cognitive performance at R were also compared. Sixteen patients with IDDM, aged 32.5 (20-45) (median (range)) years and duration of IDDM 3.0 (0.5-4.5) years participated in a randomized, double-blind study during which intravenous infusions of either Lispro or HS insulin (2.0 mU kg(-1) min(-1)) were used on separate occasions to lower the blood glucose to the level at which R was induced. For both HS and Lispro, significant increments in systolic blood pressure (p

Original language	English
Pages (from-to)	929-936
Number of pages	8
Journal	Diabetic Medicine
Volume	14
Issue number	11
DOIs	https://doi.org/10.1002/(SICI)1096-9136(199711)14:11<929::AID-DIA477>3.0.CO;2-4
Publication status	Published - Nov 1997

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10.1002/(SICI)1096-9136(199711)14:11<929::AID-DIA477>3.0.CO;2-4

http://www.ncbi.nlm.nih.gov/pubmed/9400916

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title = "Symptomatic and physiological responses to hypoglycaemia induced by human soluble insulin and the analogue Lispro human insulin",

abstract = "The aim of this study was to compare the glycaemic threshold for onset of the clinically detectable sympatho-adrenal (autonomic) reaction (defined as 'R') to hypoglycaemia induced by Lispro human insulin, with that induced by human soluble insulin (HS). The hypoglycaemia symptom profile, counterregulatory hormonal responses, and cognitive performance at R were also compared. Sixteen patients with IDDM, aged 32.5 (20-45) (median (range)) years and duration of IDDM 3.0 (0.5-4.5) years participated in a randomized, double-blind study during which intravenous infusions of either Lispro or HS insulin (2.0 mU kg(-1) min(-1)) were used on separate occasions to lower the blood glucose to the level at which R was induced. For both HS and Lispro, significant increments in systolic blood pressure (p",

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note = "M1 - 11 McCrimmon, R J Frier, B M eng Clinical Trial Comparative Study Randomized Controlled Trial Research Support, Non-U.S. Gov't ENGLAND 1997/12/24 Diabet Med. 1997 Nov;14(11):929-36.",

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T1 - Symptomatic and physiological responses to hypoglycaemia induced by human soluble insulin and the analogue Lispro human insulin

AU - McCrimmon, R. J.

AU - Frier, B. M.

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N2 - The aim of this study was to compare the glycaemic threshold for onset of the clinically detectable sympatho-adrenal (autonomic) reaction (defined as 'R') to hypoglycaemia induced by Lispro human insulin, with that induced by human soluble insulin (HS). The hypoglycaemia symptom profile, counterregulatory hormonal responses, and cognitive performance at R were also compared. Sixteen patients with IDDM, aged 32.5 (20-45) (median (range)) years and duration of IDDM 3.0 (0.5-4.5) years participated in a randomized, double-blind study during which intravenous infusions of either Lispro or HS insulin (2.0 mU kg(-1) min(-1)) were used on separate occasions to lower the blood glucose to the level at which R was induced. For both HS and Lispro, significant increments in systolic blood pressure (p

AB - The aim of this study was to compare the glycaemic threshold for onset of the clinically detectable sympatho-adrenal (autonomic) reaction (defined as 'R') to hypoglycaemia induced by Lispro human insulin, with that induced by human soluble insulin (HS). The hypoglycaemia symptom profile, counterregulatory hormonal responses, and cognitive performance at R were also compared. Sixteen patients with IDDM, aged 32.5 (20-45) (median (range)) years and duration of IDDM 3.0 (0.5-4.5) years participated in a randomized, double-blind study during which intravenous infusions of either Lispro or HS insulin (2.0 mU kg(-1) min(-1)) were used on separate occasions to lower the blood glucose to the level at which R was induced. For both HS and Lispro, significant increments in systolic blood pressure (p

U2 - 10.1002/(SICI)1096-9136(199711)14:11<929::AID-DIA477>3.0.CO;2-4

DO - 10.1002/(SICI)1096-9136(199711)14:11<929::AID-DIA477>3.0.CO;2-4

M3 - Article

SN - 0742-3071

VL - 14

SP - 929

EP - 936

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 11

ER -

Symptomatic and physiological responses to hypoglycaemia induced by human soluble insulin and the analogue Lispro human insulin

Abstract

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