Synaptic tagging and capture in the living rat

K. L. Shires, B. M. Da Silva, J. P. Hawthorne, R. G. M. Morris, S. J. Martin (Lead / Corresponding author)

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    33 Citations (Scopus)

    Abstract

    In isolated hippocampal slices, decaying long-term potentiation can be stabilized and converted to late long-term potentiation lasting many hours, by prior or subsequent strong high-frequency tetanization of an independent input to a common population of neurons-a phenomenon known as 'synaptic tagging and capture'. Here we show that the same phenomenon occurs in the intact rat. Late long-term potentiation can be induced in CA1 during the inhibition of protein synthesis if an independent input is strongly tetanized beforehand. Conversely, declining early long-term potentiation induced by weak tetanization can be converted into lasting late long-term potentiation by subsequent strong tetanization of a separate input. These findings indicate that synaptic tagging and capture is not limited to in vitro preparations; the past and future activity of neurons has a critical role in determining the persistence of synaptic changes in the living animal, thus providing a bridge between cellular studies of protein synthesis-dependent synaptic potentiation and behavioural studies of memory persistence.

    Original languageEnglish
    Article number1246
    Number of pages11
    JournalNature Communications
    Volume3
    DOIs
    Publication statusPublished - Dec 2012

    Keywords

    • LONG-TERM POTENTIATION
    • SYNTHESIS INHIBITOR ANISOMYCIN
    • LOCAL PROTEIN-SYNTHESIS
    • HIPPOCAMPAL CA1
    • FUNCTIONAL PLASTICITY
    • MEMORY FORMATION
    • SPATIAL MEMORY
    • LATE-PHASE
    • IN-VIVO
    • LTP

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