Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc

Anette Sommer, H Burkhardt, Steven M Keyse, Bernhard Lüscher

    Research output: Contribution to journalArticle

    46 Citations (Scopus)

    Abstract

    Mitogen-activated protein kinase phosphatase 1 (MKP-1) is negatively regulating mitogen-activated protein kinases and is therefore involved in early signaling processes. The expression of the mkp-1 gene is induced by growth factors and stress. The promoters of the human and murine mkp-1 genes contain several conserved DNA binding elements, including two cAMP response elements and an E box. We observed that the upstream stimulatory factor (USF), but not c-Myc, activated mkp-1. USF synergized with protein kinase A, thus providing evidence for a role of the E box, during signal-regulated stimulation of mkp-1.
    Original languageEnglish
    Pages (from-to)146-50
    Number of pages5
    JournalFEBS Letters
    Volume474
    Issue number2-3
    DOIs
    Publication statusPublished - 2 Jun 2000

    Keywords

    • Mitogen-activated protein kinase
    • mitogen-activated protein kinase phosphatase-1
    • Upstram stimulatory factor
    • MYC
    • Protein kinase A
    • Signalling

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