Abstract
Mitogen-activated protein kinase phosphatase 1 (MKP-1) is negatively regulating mitogen-activated protein kinases and is therefore involved in early signaling processes. The expression of the mkp-1 gene is induced by growth factors and stress. The promoters of the human and murine mkp-1 genes contain several conserved DNA binding elements, including two cAMP response elements and an E box. We observed that the upstream stimulatory factor (USF), but not c-Myc, activated mkp-1. USF synergized with protein kinase A, thus providing evidence for a role of the E box, during signal-regulated stimulation of mkp-1.
Original language | English |
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Pages (from-to) | 146-50 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 474 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - 2 Jun 2000 |
Keywords
- Mitogen-activated protein kinase
- mitogen-activated protein kinase phosphatase-1
- Upstram stimulatory factor
- MYC
- Protein kinase A
- Signalling