Mitogen-activated protein kinase phosphatase 1 (MKP-1) is negatively regulating mitogen-activated protein kinases and is therefore involved in early signaling processes. The expression of the mkp-1 gene is induced by growth factors and stress. The promoters of the human and murine mkp-1 genes contain several conserved DNA binding elements, including two cAMP response elements and an E box. We observed that the upstream stimulatory factor (USF), but not c-Myc, activated mkp-1. USF synergized with protein kinase A, thus providing evidence for a role of the E box, during signal-regulated stimulation of mkp-1.
- Mitogen-activated protein kinase
- mitogen-activated protein kinase phosphatase-1
- Upstram stimulatory factor
- Protein kinase A
Sommer, A., Burkhardt, H., Keyse, S. M., & Lüscher, B. (2000). Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc. FEBS Letters, 474(2-3), 146-50. https://doi.org/10.1016/S0014-5793(00)01566-0