Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc

TY - JOUR

T1 - Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc

AU - Sommer, Anette

AU - Burkhardt, H

AU - Keyse, Steven M

AU - Lüscher, Bernhard

PY - 2000/6/2

Y1 - 2000/6/2

N2 - Mitogen-activated protein kinase phosphatase 1 (MKP-1) is negatively regulating mitogen-activated protein kinases and is therefore involved in early signaling processes. The expression of the mkp-1 gene is induced by growth factors and stress. The promoters of the human and murine mkp-1 genes contain several conserved DNA binding elements, including two cAMP response elements and an E box. We observed that the upstream stimulatory factor (USF), but not c-Myc, activated mkp-1. USF synergized with protein kinase A, thus providing evidence for a role of the E box, during signal-regulated stimulation of mkp-1.

AB - Mitogen-activated protein kinase phosphatase 1 (MKP-1) is negatively regulating mitogen-activated protein kinases and is therefore involved in early signaling processes. The expression of the mkp-1 gene is induced by growth factors and stress. The promoters of the human and murine mkp-1 genes contain several conserved DNA binding elements, including two cAMP response elements and an E box. We observed that the upstream stimulatory factor (USF), but not c-Myc, activated mkp-1. USF synergized with protein kinase A, thus providing evidence for a role of the E box, during signal-regulated stimulation of mkp-1.

KW - Mitogen-activated protein kinase

KW - mitogen-activated protein kinase phosphatase-1

KW - Upstram stimulatory factor

KW - MYC

KW - Protein kinase A

KW - Signalling

U2 - 10.1016/S0014-5793(00)01566-0

DO - 10.1016/S0014-5793(00)01566-0

M3 - Article

C2 - 10838075

SN - 0014-5793

VL - 474

SP - 146

EP - 150

JO - FEBS Letters

JF - FEBS Letters

IS - 2-3

ER -