Synthesis and biological properties of bioreductively targeted nitrothienyl prodrugs of combretastatin A-4

Keyphrases

• Biological Properties 100%
• Prodrug 100%
• Combretastatin A4 Phosphate (CA4P) 100%
• Mathematical Symbols 33%
• Oxygen Concentration 33%
• Hypoxia 33%
• Anoxia 33%
• Kinetic Study 33%
• Inhibitory Effect 33%
• Whole Cell 33%
• Aerobic 33%
• Release Rate 33%
• Anticancer Therapy 33%
• Pattern Control 33%
• Radical Anions 33%
• Methyl Substitution 33%
• Cell Experiment 33%
• Ether Formation 33%
• Substitution Pattern 33%
• Nitrothiophene 33%
• Cytotoxicity 33%
• Metabolic Stability 33%
• Compound 13 33%
• Tubulin Polymerization 33%
• Carbon Substitution 33%
• Coumarin Derivatives 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Prodrug 100%
• Combretastatin A4 100%
• Polyacrylamide Gel Electrophoresis 33%
• Hypoxia 33%
• Tubulin 33%
• Methyl Group 33%
• Anoxia 33%
• Coumarin Derivative 33%
• Cytotoxicity 33%