Synthesis and characterization of an iodinated bile-salt derivative for photoaffinity-labeling

Colin J. Henderson; Ian W. Percy-Robb

doi:10.1016/0005-2760(84)90073-0

Synthesis and characterization of an iodinated bile-salt derivative for photoaffinity-labeling

Colin J. Henderson, Ian W. Percy-Robb

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2 Citations (Scopus)

Abstract

The synthesis and characterisation of a novel iodinated bile salt derivative, 125I-labelled 3ß-azidocholylhistamine, is described. The derivative is handled by rat liver in a similar manner to taurocholate and binding to bovine serum albumin, a well-characterised bile acid-binding protein, is demonstrated. The suitability of the derivative for photoaffinity labelling is assessed.

Original language	English
Pages (from-to)	257-264
Number of pages	8
Journal	Biochimica et Biophysica Acta. Lipids and Lipid Metabolism
Volume	795
Issue number	2
DOIs	https://doi.org/10.1016/0005-2760(84)90073-0
Publication status	Published - 12 Sept 1984

Keywords

Bile salt
Photoaffinity labelling
Rat liver

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10.1016/0005-2760(84)90073-0

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title = "Synthesis and characterization of an iodinated bile-salt derivative for photoaffinity-labeling",

abstract = "The synthesis and characterisation of a novel iodinated bile salt derivative, 125I-labelled 3{\ss}-azidocholylhistamine, is described. The derivative is handled by rat liver in a similar manner to taurocholate and binding to bovine serum albumin, a well-characterised bile acid-binding protein, is demonstrated. The suitability of the derivative for photoaffinity labelling is assessed.",

keywords = "Bile salt, Photoaffinity labelling, Rat liver",

author = "Henderson, {Colin J.} and Percy-Robb, {Ian W.}",

year = "1984",

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T1 - Synthesis and characterization of an iodinated bile-salt derivative for photoaffinity-labeling

AU - Henderson, Colin J.

AU - Percy-Robb, Ian W.

PY - 1984/9/12

Y1 - 1984/9/12

N2 - The synthesis and characterisation of a novel iodinated bile salt derivative, 125I-labelled 3ß-azidocholylhistamine, is described. The derivative is handled by rat liver in a similar manner to taurocholate and binding to bovine serum albumin, a well-characterised bile acid-binding protein, is demonstrated. The suitability of the derivative for photoaffinity labelling is assessed.

AB - The synthesis and characterisation of a novel iodinated bile salt derivative, 125I-labelled 3ß-azidocholylhistamine, is described. The derivative is handled by rat liver in a similar manner to taurocholate and binding to bovine serum albumin, a well-characterised bile acid-binding protein, is demonstrated. The suitability of the derivative for photoaffinity labelling is assessed.

KW - Bile salt

KW - Photoaffinity labelling

KW - Rat liver

U2 - 10.1016/0005-2760(84)90073-0

DO - 10.1016/0005-2760(84)90073-0

M3 - Article

SN - 0005-2760

VL - 795

SP - 257

EP - 264

JO - Biochimica et Biophysica Acta. Lipids and Lipid Metabolism

JF - Biochimica et Biophysica Acta. Lipids and Lipid Metabolism

IS - 2

ER -

Synthesis and characterization of an iodinated bile-salt derivative for photoaffinity-labeling

Abstract

Keywords

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