Synthesis and characterization of an iodinated bile-salt derivative for photoaffinity-labeling

Colin J. Henderson, Ian W. Percy-Robb

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    The synthesis and characterisation of a novel iodinated bile salt derivative, 125I-labelled 3ß-azidocholylhistamine, is described. The derivative is handled by rat liver in a similar manner to taurocholate and binding to bovine serum albumin, a well-characterised bile acid-binding protein, is demonstrated. The suitability of the derivative for photoaffinity labelling is assessed.
    Original languageEnglish
    Pages (from-to)257-264
    Number of pages8
    JournalBiochimica et Biophysica Acta. Lipids and Lipid Metabolism
    Issue number2
    Publication statusPublished - 12 Sep 1984


    • Bile salt
    • Photoaffinity labelling
    • Rat liver

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