Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

Mostafa M. Ghorab; Abdelaaty A. Shahat; Mansour S. Alsaid; Maureen Higgins; Albena T. Dinkova-Kostova; Almoqbl A. Naser

Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

Mostafa M. Ghorab (Lead / Corresponding author), Abdelaaty A. Shahat, Mansour S. Alsaid, Maureen Higgins, Albena T. Dinkova-Kostova, Almoqbl A. Naser

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Abstract

Acetamide derivatives and one pyridone derivative were prepared. The structure of the synthesized compounds was verified through elemental analyses,¹H -NMR and¹³C- NMR, IR spectra. The NQO1 inducer activity of the synthesized compounds was evaluated using a quantitative bioassay in Hepa1c1c7 murine hepatoma cells. The acetamide derivatives showed weak activity, with the 3-ethylphenyl being more potent than the 2-ethylphenyl derivative. The pyridone derivative was inactive.

Original language	English
Pages (from-to)	1045-1048
Number of pages	4
Journal	Biomedical Research
Volume	27
Issue number	4
Early online date	2016
Publication status	Published - 2016

Keywords

Acetamides
Electrophilicity
NQO1
Pyridone

ASJC Scopus subject areas

General Medicine
General Biochemistry,Genetics and Molecular Biology

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http://www.alliedacademies.org/articles/synthesis-and-nadph-quinone-oxidoreductase-1-inducer-activity-of-acetamide-and-pyridine3carbonitrile-derivatives.htmlLicence: CC BY

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Ghorab, M. M., Shahat, A. A., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., & Naser, A. A. (2016). Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives. Biomedical Research, 27(4), 1045-1048. http://www.alliedacademies.org/articles/synthesis-and-nadph-quinone-oxidoreductase-1-inducer-activity-of-acetamide-and-pyridine3carbonitrile-derivatives.html

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title = "Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives",

abstract = "Acetamide derivatives and one pyridone derivative were prepared. The structure of the synthesized compounds was verified through elemental analyses,1H -NMR and13C- NMR, IR spectra. The NQO1 inducer activity of the synthesized compounds was evaluated using a quantitative bioassay in Hepa1c1c7 murine hepatoma cells. The acetamide derivatives showed weak activity, with the 3-ethylphenyl being more potent than the 2-ethylphenyl derivative. The pyridone derivative was inactive.",

keywords = "Acetamides, Electrophilicity, NQO1, Pyridone",

author = "Ghorab, {Mostafa M.} and Shahat, {Abdelaaty A.} and Alsaid, {Mansour S.} and Maureen Higgins and Dinkova-Kostova, {Albena T.} and Naser, {Almoqbl A.}",

note = "Mostafa M. Ghorab1, Abdelaaty A. Shahat and Mansour S. Alsaid extend their truthful appreciation to the Deanship of Scientific Research at King Saud University for funding of this research through the Research Group Project no. RGPVPP-262. Maureen Higgins and Albena T. Dinkova-Kostova are also grateful to Cancer Research UK (C20953/A10270) for financial support.",

year = "2016",

language = "English",

volume = "27",

pages = "1045--1048",

journal = "Biomedical Research",

issn = "0970-938X",

publisher = "Scientific Publishers of India",

number = "4",

}

Ghorab, MM, Shahat, AA, Alsaid, MS, Higgins, M, Dinkova-Kostova, AT & Naser, AA 2016, 'Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives', Biomedical Research, vol. 27, no. 4, pp. 1045-1048. <http://www.alliedacademies.org/articles/synthesis-and-nadph-quinone-oxidoreductase-1-inducer-activity-of-acetamide-and-pyridine3carbonitrile-derivatives.html>

TY - JOUR

T1 - Synthesis and NAD(P)H

T2 - Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

AU - Ghorab, Mostafa M.

AU - Shahat, Abdelaaty A.

AU - Alsaid, Mansour S.

AU - Higgins, Maureen

AU - Dinkova-Kostova, Albena T.

AU - Naser, Almoqbl A.

N1 - Mostafa M. Ghorab1, Abdelaaty A. Shahat and Mansour S. Alsaid extend their truthful appreciation to the Deanship of Scientific Research at King Saud University for funding of this research through the Research Group Project no. RGPVPP-262. Maureen Higgins and Albena T. Dinkova-Kostova are also grateful to Cancer Research UK (C20953/A10270) for financial support.

PY - 2016

Y1 - 2016

N2 - Acetamide derivatives and one pyridone derivative were prepared. The structure of the synthesized compounds was verified through elemental analyses,1H -NMR and13C- NMR, IR spectra. The NQO1 inducer activity of the synthesized compounds was evaluated using a quantitative bioassay in Hepa1c1c7 murine hepatoma cells. The acetamide derivatives showed weak activity, with the 3-ethylphenyl being more potent than the 2-ethylphenyl derivative. The pyridone derivative was inactive.

AB - Acetamide derivatives and one pyridone derivative were prepared. The structure of the synthesized compounds was verified through elemental analyses,1H -NMR and13C- NMR, IR spectra. The NQO1 inducer activity of the synthesized compounds was evaluated using a quantitative bioassay in Hepa1c1c7 murine hepatoma cells. The acetamide derivatives showed weak activity, with the 3-ethylphenyl being more potent than the 2-ethylphenyl derivative. The pyridone derivative was inactive.

KW - Acetamides

KW - Electrophilicity

KW - NQO1

KW - Pyridone

UR - http://www.scopus.com/inward/record.url?scp=84988667523&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84988667523

SN - 0970-938X

VL - 27

SP - 1045

EP - 1048

JO - Biomedical Research

JF - Biomedical Research

IS - 4

ER -

Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

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Keywords

ASJC Scopus subject areas

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