Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

Mostafa M. Ghorab (Lead / Corresponding author), Abdelaaty A. Shahat, Mansour S. Alsaid, Maureen Higgins, Albena T. Dinkova-Kostova, Almoqbl A. Naser

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    Abstract

    Acetamide derivatives and one pyridone derivative were prepared. The structure of the synthesized compounds was verified through elemental analyses,1H -NMR and13C- NMR, IR spectra. The NQO1 inducer activity of the synthesized compounds was evaluated using a quantitative bioassay in Hepa1c1c7 murine hepatoma cells. The acetamide derivatives showed weak activity, with the 3-ethylphenyl being more potent than the 2-ethylphenyl derivative. The pyridone derivative was inactive.

    Original languageEnglish
    Pages (from-to)1045-1048
    Number of pages4
    JournalBiomedical Research
    Volume27
    Issue number4
    Early online date2016
    Publication statusPublished - 2016

    Keywords

    • Acetamides
    • Electrophilicity
    • NQO1
    • Pyridone

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