Abstract
Acetamide derivatives and one pyridone derivative were prepared. The structure of the synthesized compounds was verified through elemental analyses,1H -NMR and13C- NMR, IR spectra. The NQO1 inducer activity of the synthesized compounds was evaluated using a quantitative bioassay in Hepa1c1c7 murine hepatoma cells. The acetamide derivatives showed weak activity, with the 3-ethylphenyl being more potent than the 2-ethylphenyl derivative. The pyridone derivative was inactive.
Original language | English |
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Pages (from-to) | 1045-1048 |
Number of pages | 4 |
Journal | Biomedical Research |
Volume | 27 |
Issue number | 4 |
Early online date | 2016 |
Publication status | Published - 2016 |
Keywords
- Acetamides
- Electrophilicity
- NQO1
- Pyridone
ASJC Scopus subject areas
- General Medicine
- General Biochemistry,Genetics and Molecular Biology