Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

Mostafa M. Ghorab; Abdelaaty A. Shahat; Mansour S. Alsaid; Maureen Higgins; Albena T. Dinkova-Kostova; Almoqbl A. Naser

Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

Mostafa M. Ghorab (Lead / Corresponding author), Abdelaaty A. Shahat, Mansour S. Alsaid, Maureen Higgins, Albena T. Dinkova-Kostova, Almoqbl A. Naser

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Abstract

Acetamide derivatives and one pyridone derivative were prepared. The structure of the synthesized compounds was verified through elemental analyses,¹H -NMR and¹³C- NMR, IR spectra. The NQO1 inducer activity of the synthesized compounds was evaluated using a quantitative bioassay in Hepa1c1c7 murine hepatoma cells. The acetamide derivatives showed weak activity, with the 3-ethylphenyl being more potent than the 2-ethylphenyl derivative. The pyridone derivative was inactive.

Original language	English
Pages (from-to)	1045-1048
Number of pages	4
Journal	Biomedical Research
Volume	27
Issue number	4
Early online date	2016
Publication status	Published - 2016

Keywords

Acetamides
Electrophilicity
NQO1
Pyridone

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Ghorab, M. M., Shahat, A. A., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., & Naser, A. A. (2016). Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives. Biomedical Research, 27(4), 1045-1048. http://www.alliedacademies.org/articles/synthesis-and-nadph-quinone-oxidoreductase-1-inducer-activity-of-acetamide-and-pyridine3carbonitrile-derivatives.html

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title = "Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives",

abstract = "Acetamide derivatives and one pyridone derivative were prepared. The structure of the synthesized compounds was verified through elemental analyses,1H -NMR and13C- NMR, IR spectra. The NQO1 inducer activity of the synthesized compounds was evaluated using a quantitative bioassay in Hepa1c1c7 murine hepatoma cells. The acetamide derivatives showed weak activity, with the 3-ethylphenyl being more potent than the 2-ethylphenyl derivative. The pyridone derivative was inactive.",

keywords = "Acetamides, Electrophilicity, NQO1, Pyridone",

author = "Ghorab, {Mostafa M.} and Shahat, {Abdelaaty A.} and Alsaid, {Mansour S.} and Maureen Higgins and Dinkova-Kostova, {Albena T.} and Naser, {Almoqbl A.}",

note = "Mostafa M. Ghorab1, Abdelaaty A. Shahat and Mansour S. Alsaid extend their truthful appreciation to the Deanship of Scientific Research at King Saud University for funding of this research through the Research Group Project no. RGPVPP-262. Maureen Higgins and Albena T. Dinkova-Kostova are also grateful to Cancer Research UK (C20953/A10270) for financial support.",

year = "2016",

language = "English",

volume = "27",

pages = "1045--1048",

journal = "Biomedical Research",

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Ghorab, MM, Shahat, AA, Alsaid, MS, Higgins, M, Dinkova-Kostova, AT & Naser, AA 2016, 'Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives', Biomedical Research, vol. 27, no. 4, pp. 1045-1048. <http://www.alliedacademies.org/articles/synthesis-and-nadph-quinone-oxidoreductase-1-inducer-activity-of-acetamide-and-pyridine3carbonitrile-derivatives.html>

Synthesis and NAD(P)H : Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives. / Ghorab, Mostafa M. (Lead / Corresponding author); Shahat, Abdelaaty A.; Alsaid, Mansour S.; Higgins, Maureen; Dinkova-Kostova, Albena T.; Naser, Almoqbl A.

In: Biomedical Research, Vol. 27, No. 4, 2016, p. 1045-1048.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Synthesis and NAD(P)H

T2 - Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

AU - Ghorab, Mostafa M.

AU - Shahat, Abdelaaty A.

AU - Alsaid, Mansour S.

AU - Higgins, Maureen

AU - Dinkova-Kostova, Albena T.

AU - Naser, Almoqbl A.

N1 - Mostafa M. Ghorab1, Abdelaaty A. Shahat and Mansour S. Alsaid extend their truthful appreciation to the Deanship of Scientific Research at King Saud University for funding of this research through the Research Group Project no. RGPVPP-262. Maureen Higgins and Albena T. Dinkova-Kostova are also grateful to Cancer Research UK (C20953/A10270) for financial support.

PY - 2016

Y1 - 2016

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KW - Electrophilicity

KW - NQO1

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