@article{ff7f24f9878843b18a39ad96b9ce943b,
title = "Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives",
abstract = "Acetamide derivatives and one pyridone derivative were prepared. The structure of the synthesized compounds was verified through elemental analyses,1H -NMR and13C- NMR, IR spectra. The NQO1 inducer activity of the synthesized compounds was evaluated using a quantitative bioassay in Hepa1c1c7 murine hepatoma cells. The acetamide derivatives showed weak activity, with the 3-ethylphenyl being more potent than the 2-ethylphenyl derivative. The pyridone derivative was inactive.",
keywords = "Acetamides, Electrophilicity, NQO1, Pyridone",
author = "Ghorab, {Mostafa M.} and Shahat, {Abdelaaty A.} and Alsaid, {Mansour S.} and Maureen Higgins and Dinkova-Kostova, {Albena T.} and Naser, {Almoqbl A.}",
note = "Mostafa M. Ghorab1, Abdelaaty A. Shahat and Mansour S. Alsaid extend their truthful appreciation to the Deanship of Scientific Research at King Saud University for funding of this research through the Research Group Project no. RGPVPP-262. Maureen Higgins and Albena T. Dinkova-Kostova are also grateful to Cancer Research UK (C20953/A10270) for financial support.",
year = "2016",
language = "English",
volume = "27",
pages = "1045--1048",
journal = "Biomedical Research",
issn = "0970-938X",
publisher = "Scientific Publishers of India",
number = "4",
}