Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens

Bini Mathew, Judith V. Hobrath, Wenyan Lu, Yonghe Li, Robert C. Reynolds (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
178 Downloads (Pure)

Abstract

As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of NSAID amide derivatives and screened these sets against three cancer cell lines (prostate, colon and breast) and Wnt/β-catenin signaling. The evaluated amide analog libraries show significant anticancer activity/cell proliferation inhibition, and specific members of the sets show inhibition of Wnt/β-catenin signaling.

Original languageEnglish
Pages (from-to)3038-3045
Number of pages8
JournalMedicinal Chemistry Research
Volume26
Issue number11
Early online date5 Aug 2017
DOIs
Publication statusPublished - Nov 2017

Keywords

  • Amides
  • Cancer
  • Fenamates
  • NSAIDs
  • Wnt/β-catenin

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