Abstract
As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of NSAID amide derivatives and screened these sets against three cancer cell lines (prostate, colon and breast) and Wnt/β-catenin signaling. The evaluated amide analog libraries show significant anticancer activity/cell proliferation inhibition, and specific members of the sets show inhibition of Wnt/β-catenin signaling.
Original language | English |
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Pages (from-to) | 3038-3045 |
Number of pages | 8 |
Journal | Medicinal Chemistry Research |
Volume | 26 |
Issue number | 11 |
Early online date | 5 Aug 2017 |
DOIs | |
Publication status | Published - Nov 2017 |
Keywords
- Amides
- Cancer
- Fenamates
- NSAIDs
- Wnt/β-catenin
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Organic Chemistry