The aim of this research was to investigate zinc chromium ferrite (ZnCrFeO) nanoparticles, synthesized using the sol gel technique with nanoparticle size controlled through a two-stage annealing process. Stage one was a low temperature firing which produced low quality nanocrystals with an average size of 15 nm. This was followed by a second firing stage at high temperature which enhanced the crystal quality. The nanoparticles were then coated with a bio-compatible shell to form a stable suspension in the ferrofluid carrier. The resulting nanoparticles were found by electron microscopy, atomic force microscopy and X-ray diffraction studies to have excellent crystal quality. The average size was 8.5 nm. Preliminary cell culture studies indicated the ZnCrFeO nanoparticles were non-toxic. The relatively high measured value of the relaxivity r showed that the nanoparticle coating was effective in substantially reducing aggregation and enhancing the properties of the nanoparticles associated with contrast enhancement in MRI.
|Number of pages||6|
|Journal||Materials Science & Engineering C - Biomimetic and Supramolecular Systems|
|Publication status||Published - 1 Apr 2013|