Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2

Osama I. G. Khreit, Craig Irving, Elke Schimdt, John A. Parkinson, Niamh Nic Daeid, Oliver B. Sutcliffe (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

The recent global increase in the abuse of 4'-methylmethcathinone (mephedrone) and related compounds has developed a requirement for full chemical characterisation of these products. This work presents full synthetic and chemical characterisation data for the hydrobromide salts of two mephedrone derivatives: 4'-methyl-N-ethylcathinone (4-MEC) and 4'-methyl-N-benzylcathinone (4-MBC) which have been identified in samples of the " legal high" NRG-2. The first fully validated chromatographic methods for the detection and quantitative analysis of these substances both in their pure form and in the presence of a number of common adulterants used in illicit drug manufacture is also reported.
Original languageEnglish
Pages (from-to)122-135
Number of pages14
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume61
DOIs
Publication statusPublished - 5 Mar 2012

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