Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone): A new "legal high"

Eman Y. Santali; Anna-Karina Cadogan; Niamh Nic Daeid; Kathleen A. Savage; Oliver B. Sutcliffe

doi:10.1016/j.jpba.2011.05.022

Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone): A new "legal high"

Eman Y. Santali, Anna-Karina Cadogan, Niamh Nic Daeid, Kathleen A. Savage, Oliver B. Sutcliffe (Lead / Corresponding author)

Leverhulme Research Centre for Forensic Science

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

The recent global increase in the abuse of 4'-methylmethcathinone and related compounds has developed a requirement for full chemical characterisation of these products. In this work we present full synthetic and chemical characterisation data and supplemental information for mephedrone synthesised as both the hydrobromide and hydrochloride salt. Additionally we report the first fully validated chromatographic methods for the detection and quantitative analysis of the substance both in its pure form and in the presence of a number of common adulterants used in illicit drug manufacture.

Original language	English
Pages (from-to)	246-255
Number of pages	10
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	56
Issue number	2
DOIs	https://doi.org/10.1016/j.jpba.2011.05.022
Publication status	Published - 10 Sept 2011

Keywords

Mephedrone, Cathinone, legal high, analytical profiling, HPLC, Methcathionoe , 4-Methlymethcathinone, toxicity, Chemistry, Drug Discovery, Pharmaceutical Science, Spectroscopy, Analytical Chemistry, Clinical Biochemistry

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10.1016/j.jpba.2011.05.022

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abstract = "The recent global increase in the abuse of 4'-methylmethcathinone and related compounds has developed a requirement for full chemical characterisation of these products. In this work we present full synthetic and chemical characterisation data and supplemental information for mephedrone synthesised as both the hydrobromide and hydrochloride salt. Additionally we report the first fully validated chromatographic methods for the detection and quantitative analysis of the substance both in its pure form and in the presence of a number of common adulterants used in illicit drug manufacture.",

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Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone): A new "legal high". / Santali, Eman Y.; Cadogan, Anna-Karina; Nic Daeid, Niamh et al.
In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 56, No. 2, 10.09.2011, p. 246-255.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone)

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AU - Santali, Eman Y.

AU - Cadogan, Anna-Karina

AU - Nic Daeid, Niamh

AU - Savage, Kathleen A.

AU - Sutcliffe, Oliver B.

PY - 2011/9/10

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AB - The recent global increase in the abuse of 4'-methylmethcathinone and related compounds has developed a requirement for full chemical characterisation of these products. In this work we present full synthetic and chemical characterisation data and supplemental information for mephedrone synthesised as both the hydrobromide and hydrochloride salt. Additionally we report the first fully validated chromatographic methods for the detection and quantitative analysis of the substance both in its pure form and in the presence of a number of common adulterants used in illicit drug manufacture.

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SN - 0731-7085

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Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone): A new "legal high"

Abstract

Keywords

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