Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2

Osama I. G. Khreit; Craig Irving; Elke Schimdt; John A. Parkinson; Niamh Nic Daeid; Oliver B. Sutcliffe

doi:10.1016/j.jpba.2011.11.004

Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2

Osama I. G. Khreit
, Craig Irving
, Elke Schimdt
, John A. Parkinson
, Niamh Nic Daeid
, Oliver B. Sutcliffe (Lead / Corresponding author)

Leverhulme Research Centre for Forensic Science

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The recent global increase in the abuse of 4'-methylmethcathinone (mephedrone) and related compounds has developed a requirement for full chemical characterisation of these products. This work presents full synthetic and chemical characterisation data for the hydrobromide salts of two mephedrone derivatives: 4'-methyl-N-ethylcathinone (4-MEC) and 4'-methyl-N-benzylcathinone (4-MBC) which have been identified in samples of the " legal high" NRG-2. The first fully validated chromatographic methods for the detection and quantitative analysis of these substances both in their pure form and in the presence of a number of common adulterants used in illicit drug manufacture is also reported.

Original language	English
Pages (from-to)	122-135
Number of pages	14
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	61
DOIs	https://doi.org/10.1016/j.jpba.2011.11.004
Publication status	Published - 5 Mar 2012

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10.1016/j.jpba.2011.11.004

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Khreit, O. I. G., Irving, C., Schimdt, E., Parkinson, J. A., Nic Daeid, N., & Sutcliffe, O. B. (2012). Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2. Journal of Pharmaceutical and Biomedical Analysis, 61, 122-135. https://doi.org/10.1016/j.jpba.2011.11.004

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Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2. / Khreit, Osama I. G.; Irving, Craig; Schimdt, Elke et al.
In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 61, 05.03.2012, p. 122-135.

Research output: Contribution to journal › Article › peer-review

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AU - Khreit, Osama I. G.

AU - Irving, Craig

AU - Schimdt, Elke

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AU - Nic Daeid, Niamh

AU - Sutcliffe, Oliver B.

PY - 2012/3/5

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AB - The recent global increase in the abuse of 4'-methylmethcathinone (mephedrone) and related compounds has developed a requirement for full chemical characterisation of these products. This work presents full synthetic and chemical characterisation data for the hydrobromide salts of two mephedrone derivatives: 4'-methyl-N-ethylcathinone (4-MEC) and 4'-methyl-N-benzylcathinone (4-MBC) which have been identified in samples of the " legal high" NRG-2. The first fully validated chromatographic methods for the detection and quantitative analysis of these substances both in their pure form and in the presence of a number of common adulterants used in illicit drug manufacture is also reported.

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SN - 0731-7085

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JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

ER -

Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2

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