Synthesis of β-keto and α,β-unsaturated N-acetylcysteamine thioesters

Ian H. Gilbert; Mark Ginty; John A. O'Neill; Thomas J. Simpson; James Staunton; Christine L. Willis

doi:10.1016/0960-894X(95)00276-Y

Synthesis of β-keto and α,β-unsaturated N-acetylcysteamine thioesters

Ian H. Gilbert, Mark Ginty, John A. O'Neill, Thomas J. Simpson, James Staunton, Christine L. Willis

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Abstract

Methods for the synthesis of N-acetylcysteamine thioesters of beta-keto and alpha,beta-unsaturated acids which avoid problems associated with methods requiring the intermediacy of the free acids are described, along with a convenient method for the removal of excess thiol from reaction mixtures using copper sulphate impregnated silica.

Original language	English
Pages (from-to)	1587-1590
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	5
Issue number	15
DOIs	https://doi.org/10.1016/0960-894X(95)00276-Y
Publication status	Published - 1995

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@article{35a59369e3444315add4e4177503c407,

title = "Synthesis of β-keto and α,β-unsaturated N-acetylcysteamine thioesters",

abstract = "Methods for the synthesis of N-acetylcysteamine thioesters of beta-keto and alpha,beta-unsaturated acids which avoid problems associated with methods requiring the intermediacy of the free acids are described, along with a convenient method for the removal of excess thiol from reaction mixtures using copper sulphate impregnated silica.",

author = "Gilbert, \{Ian H.\} and Mark Ginty and O'Neill, \{John A.\} and Simpson, \{Thomas J.\} and James Staunton and Willis, \{Christine L.\}",

year = "1995",

doi = "10.1016/0960-894X(95)00276-Y",

language = "English",

volume = "5",

pages = "1587--1590",

journal = "Bioorganic \& Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier",

number = "15",

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TY - JOUR

T1 - Synthesis of β-keto and α,β-unsaturated N-acetylcysteamine thioesters

AU - Gilbert, Ian H.

AU - Ginty, Mark

AU - O'Neill, John A.

AU - Simpson, Thomas J.

AU - Staunton, James

AU - Willis, Christine L.

PY - 1995

Y1 - 1995

N2 - Methods for the synthesis of N-acetylcysteamine thioesters of beta-keto and alpha,beta-unsaturated acids which avoid problems associated with methods requiring the intermediacy of the free acids are described, along with a convenient method for the removal of excess thiol from reaction mixtures using copper sulphate impregnated silica.

AB - Methods for the synthesis of N-acetylcysteamine thioesters of beta-keto and alpha,beta-unsaturated acids which avoid problems associated with methods requiring the intermediacy of the free acids are described, along with a convenient method for the removal of excess thiol from reaction mixtures using copper sulphate impregnated silica.

U2 - 10.1016/0960-894X(95)00276-Y

DO - 10.1016/0960-894X(95)00276-Y

M3 - Article

SN - 0960-894X

VL - 5

SP - 1587

EP - 1590

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 15

ER -

Synthesis of β-keto and α,β-unsaturated N-acetylcysteamine thioesters

Abstract

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