Synthesis of β-keto and α,β-unsaturated N-acetylcysteamine thioesters

Ian H. Gilbert, Mark Ginty, John A. O'Neill, Thomas J. Simpson, James Staunton, Christine L. Willis

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    Abstract

    Methods for the synthesis of N-acetylcysteamine thioesters of beta-keto and alpha,beta-unsaturated acids which avoid problems associated with methods requiring the intermediacy of the free acids are described, along with a convenient method for the removal of excess thiol from reaction mixtures using copper sulphate impregnated silica.

    Original languageEnglish
    Pages (from-to)1587-1590
    Number of pages4
    JournalBioorganic & Medicinal Chemistry Letters
    Volume5
    Issue number15
    DOIs
    Publication statusPublished - 1995

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