Abstract
4'-Thionucleosides, where the furanose ring oxygen is replaced with sulfur, have attracted significant interest due to their biological activity and metabolic stability. In recent years, a growing number of reports have detailed the chemical synthesis and evaluation of 4'-thio nucleoside analogs, alongside methodologies for the provision of thiosugar-containing scaffolds. The original report for synthesizing was made by Imbach and coworkers in their synthesis of 4'-thio-ß-d-oligoribonucleotides and utilized as the starting material, recording a 38% yield for the two-step process. NMR analysis confirmed the correct structure notably with the presence of signals for the alkene in the nucleobase with vicinal coupling to each other.
Original language | English |
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Title of host publication | Carbohydrate Chemistry |
Subtitle of host publication | Proven Synthetic Methods |
Editors | Paul Kosma, Tanja Wrodnigg, Arnold Stütz |
Place of Publication | Boca Raton |
Publisher | CRC Press |
Chapter | 28 |
Number of pages | 6 |
Volume | 5 |
Edition | 1 |
ISBN (Electronic) | 9781351256087 |
ISBN (Print) | 9780815367888 (hbk), 9780367561734 (pbk) |
DOIs | |
Publication status | Published - 2021 |