4'-Thionucleosides, where the furanose ring oxygen is replaced with sulfur, have attracted significant interest due to their biological activity and metabolic stability. In recent years, a growing number of reports have detailed the chemical synthesis and evaluation of 4'-thio nucleoside analogs, alongside methodologies for the provision of thiosugar-containing scaffolds. The original report for synthesizing was made by Imbach and coworkers in their synthesis of 4'-thio-ß-d-oligoribonucleotides and utilized as the starting material, recording a 38% yield for the two-step process. NMR analysis confirmed the correct structure notably with the presence of signals for the alkene in the nucleobase with vicinal coupling to each other.
|Title of host publication||Carbohydrate Chemistry|
|Subtitle of host publication||Proven Synthetic Methods|
|Editors||Paul Kosma, Tanja Wrodnigg, Arnold Stütz|
|Place of Publication||Boca Raton|
|Number of pages||6|
|ISBN (Print)||9780815367888 (hbk), 9780367561734 (pbk)|
|Publication status||Published - 2021|