Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis

Arthur T. Crossman; Michael D. Urbaniak; Michael A. J. Ferguson

doi:10.1016/j.carres.2008.03.028

Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis

Arthur T. Crossman, Michael D. Urbaniak, Michael A. J. Ferguson

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

1-D-6-O-[2-(N-Hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate) was prepared to probe the reaction mechanism of the putative zinc-dependent metalloenzyme 2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1-->6)-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis. (C) 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	1478-1481
Number of pages	4
Journal	Carbohydrate Research
Volume	343
Issue number	9
DOIs	https://doi.org/10.1016/j.carres.2008.03.028
Publication status	Published - 7 Jul 2008

Keywords

glycosylphosphatidylinositol (GPI) membrane anchors
N-hydroxyurea
zinc metalloenzyme inhibitor
N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase
DE-N-ACETYLASE
AFRICAN SLEEPING SICKNESS
TRYPANOSOMA-BRUCEI
MEMBRANE ANCHORS
GPI BIOSYNTHESIS
PHOSPHATIDYLINOSITOL
PARASITE
PATHWAY
SPECIFICITIES
GLUCOSAMINE

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{9ac7cde7a1314be8a34622ce4d42db2a,

title = "Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis",

abstract = "1-D-6-O-[2-(N-Hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate) was prepared to probe the reaction mechanism of the putative zinc-dependent metalloenzyme 2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1-->6)-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis. (C) 2008 Elsevier Ltd. All rights reserved.",

keywords = "glycosylphosphatidylinositol (GPI) membrane anchors, N-hydroxyurea, zinc metalloenzyme inhibitor, N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, DE-N-ACETYLASE, AFRICAN SLEEPING SICKNESS, TRYPANOSOMA-BRUCEI, MEMBRANE ANCHORS, GPI BIOSYNTHESIS, PHOSPHATIDYLINOSITOL, PARASITE, PATHWAY, SPECIFICITIES, GLUCOSAMINE",

author = "Crossman, {Arthur T.} and Urbaniak, {Michael D.} and Ferguson, {Michael A. J.}",

year = "2008",

month = jul,

day = "7",

doi = "10.1016/j.carres.2008.03.028",

language = "English",

volume = "343",

pages = "1478--1481",

journal = "Carbohydrate Research",

issn = "0008-6215",

publisher = "Elsevier",

number = "9",

}

Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis. / Crossman, Arthur T.; Urbaniak, Michael D.; Ferguson, Michael A. J.
In: Carbohydrate Research, Vol. 343, No. 9, 07.07.2008, p. 1478-1481.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate)

T2 - a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis

AU - Crossman, Arthur T.

AU - Urbaniak, Michael D.

AU - Ferguson, Michael A. J.

PY - 2008/7/7

Y1 - 2008/7/7

N2 - 1-D-6-O-[2-(N-Hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate) was prepared to probe the reaction mechanism of the putative zinc-dependent metalloenzyme 2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1-->6)-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis. (C) 2008 Elsevier Ltd. All rights reserved.

AB - 1-D-6-O-[2-(N-Hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate) was prepared to probe the reaction mechanism of the putative zinc-dependent metalloenzyme 2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1-->6)-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis. (C) 2008 Elsevier Ltd. All rights reserved.

KW - glycosylphosphatidylinositol (GPI) membrane anchors

KW - N-hydroxyurea

KW - zinc metalloenzyme inhibitor

KW - N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase

KW - DE-N-ACETYLASE

KW - AFRICAN SLEEPING SICKNESS

KW - TRYPANOSOMA-BRUCEI

KW - MEMBRANE ANCHORS

KW - GPI BIOSYNTHESIS

KW - PHOSPHATIDYLINOSITOL

KW - PARASITE

KW - PATHWAY

KW - SPECIFICITIES

KW - GLUCOSAMINE

U2 - 10.1016/j.carres.2008.03.028

DO - 10.1016/j.carres.2008.03.028

M3 - Article

C2 - 18479678

SN - 0008-6215

VL - 343

SP - 1478

EP - 1481

JO - Carbohydrate Research

JF - Carbohydrate Research

IS - 9

ER -