Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis

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    Abstract

    1-D-6-O-[2-(N-Hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate) was prepared to probe the reaction mechanism of the putative zinc-dependent metalloenzyme 2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1-->6)-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis. (C) 2008 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)1478-1481
    Number of pages4
    JournalCarbohydrate Research
    Volume343
    Issue number9
    DOIs
    Publication statusPublished - 7 Jul 2008

    Keywords

    • glycosylphosphatidylinositol (GPI) membrane anchors
    • N-hydroxyurea
    • zinc metalloenzyme inhibitor
    • N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase
    • DE-N-ACETYLASE
    • AFRICAN SLEEPING SICKNESS
    • TRYPANOSOMA-BRUCEI
    • MEMBRANE ANCHORS
    • GPI BIOSYNTHESIS
    • PHOSPHATIDYLINOSITOL
    • PARASITE
    • PATHWAY
    • SPECIFICITIES
    • GLUCOSAMINE

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