Synthesis of 3 '-, 4 '- and 6 '-deoxy and other analogues of D-glucosaminylphosphatidylinositol

Charles N. Borissow, Terry K. Smith, Michael A. J. Ferguson, John S. Brimacombe

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    Abstract

    Deoxy and other analogues of D-glucosaminylphosphatidylinositol 1 have been synthesised and tested as substrates or inhibitors of a de-N-acetylase and mannosyltransferase (MT-1) involved in the biosynthesis of the glycosylphosphatidylinositol (GPI) membrane anchor of the parasite Trypanosoma brucei. (C) 2000 Elsevier Science Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)121-123
    Number of pages3
    JournalTetrahedron Letters
    Volume42
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2001

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