Synthesis of 3,3-disubstituted heterocycles by Pd-catalyzed arylallylation of unactivated alkenes

David Phillips, Joanne F.M. Hewitt, David J. France

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
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Abstract

Finding new methods of carbon-carbon bond formation is a key goal in expanding current methodology for heterocycle formation. Because of their inherently nonplanar shape, new methods of forming sp3-rich scaffolds are of particular importance. Although there are methods for combining heterocyclization and formation of new sp3-sp3 carbon-carbon bonds, these form the carbon-heteroatom bond rather than a carbon-carbon bond of the heterocycle. Here, we show a new alkene arylallylation reaction that generates a heterocycle with concomitant formation of two new carbon-carbon bonds. Furthermore, we demonstrate that this process occurs through an isohypsic (redox neutral) mechanism. Overall, this carboallylation reaction gives a new route to the synthesis of 3,3-disubstituted heterocycles.

Original languageEnglish
Pages (from-to)8451-8459
Number of pages9
JournalACS Omega
Volume3
Issue number7
DOIs
Publication statusPublished - 31 Jul 2018

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