Synthesis of a cell-permeable analogue of a glycosylphosphatidylinositol (GPI) intermediate that is toxic to the living bloodstream form of Trypanosoma brucei

Arthur Crossman, Terry K Smith, Michael A J Ferguson, John S Brimacombe

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    Abstract

    The synthesis of two cell-permeable analogues related to a GPI intermediate is described for studies with living trypano-somes and human (HeLa) cells. One of the analogues is metabolised by the former GPI pathway and is toxic to the parasite Try-panosoma brucei but not to human cells. (c) 2005 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)7419-7421
    Number of pages3
    JournalTetrahedron Letters
    Volume46
    Issue number43
    DOIs
    Publication statusPublished - 24 Oct 2005

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